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Naslov:The role of methylation of host and/or human papillomavirus (HPV) DNA in management of cervical intraepithelial neoplasia grade 2 (CIN2) lesions
Avtorji:ID Dovnik, Andraž (Avtor)
ID Poljak, Mario (Avtor)
Datoteke:.pdf Dovnik-2023-The_Role_of_Methylation_of_Host_an.pdf (340,44 KB)
MD5: D777FB9E07172E6F5C5BF12E8A615B75
 
URL https://doi.org/10.3390/ijms24076479
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:Cervical intraepithelial neoplasia grade 2 (CIN2) is an intermediate stage between CIN 1, which is a low-grade lesion, and CIN3, which is the immediate precursor of cervical cancer (CC). Traditionally, CIN2 was regarded as a high-grade lesion and was treated with conization or ablative methods. In recent years, there has been a shift in the management of younger patients, who are now more often being managed conservatively due to frequent spontaneous CIN2 regression and possible adverse effects of treatment on future pregnancies. Because the risk of progression to CC still exists with conservative management, a personalized approach is needed to identify patients with a higher probability of progression. In this regard, research has focused on the role of host and human papillomavirus (HPV) gene methylation. This systematic review summarizes the current knowledge regarding conservative CIN2 management focusing on the main methylation markers and its implementation in conservative CIN2 management, and it describes major ongoing longitudinal studies on the subject. The review showed that DNA methylation is an accurate predictor of disease progression and a valid triage tool for HPV-positive women, with CIN2 performing better than triage cytology. Because virtually all CCs are methylation-positive, methylation-negative women at baseline have an extremely low risk of CC.
Ključne besede:cervical intraepithelial lesion, human papillomavirus, gene methylation
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Poslano v recenzijo:07.03.2023
Datum sprejetja članka:28.03.2023
Datum objave:30.03.2023
Založnik:MDPI
Leto izida:2023
Št. strani:Str. 1-15
Številčenje:Letn. 24, Št. 7, št. članka 6479
PID:20.500.12556/DKUM-89543 Novo okno
UDK:618.1
COBISS.SI-ID:147516675 Novo okno
DOI:10.3390/ ijms24076479 Novo okno
ISSN pri članku:1422-0067
Datum objave v DKUM:19.07.2024
Število ogledov:169
Število prenosov:10
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
DOVNIK, Andraž in POLJAK, Mario, 2023, The role of methylation of host and/or human papillomavirus (HPV) DNA in management of cervical intraepithelial neoplasia grade 2 (CIN2) lesions. International journal of molecular sciences [na spletu]. 2023. Vol. 24, no. Št. 7,  članka 6479, p. 1–15. [Dostopano 26 marec 2025]. DOI 10.3390/ ijms24076479. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=89543
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Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Novo okno

Gradivo je financirano iz projekta

Financer:EC - European Commission
Program financ.:H2020
Številka projekta:847845
Naslov:RISK-BASED SCREENING FOR CERVICAL CANCER
Akronim:RISCC
Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0083
Naslov:Odnosi parazitskega obstajanja

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:30.03.2023

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:intraepitelijska lezija materničnega vratu, človeški papiloma virus, metilacija genov


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