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Naslov:Medication use in uncontrolled pediatric asthma : results from the SysPharmPediA study
Avtorji:ID Alizadeh Bahmani, Amir Hossein (Avtor)
ID Slob, Elise M. A. (Avtor)
ID Bloemsma, Lizan D. (Avtor)
ID Brandstetter, Susanne (Avtor)
ID Corcuerea, Paula (Avtor)
ID Gorenjak, Mario (Avtor)
ID Harner, Susanne (Avtor)
ID Hashimoto, Simone (Avtor)
ID Hedman, Anna M. (Avtor)
ID Kabesch, Michael (Avtor)
ID Potočnik, Uroš (Avtor)
Datoteke:.pdf Medication_use_in_uncontrolled_pe-Bahmani-2022.pdf (639,57 KB)
MD5: 18DFB97A500929AFACD9A23A893A46BB
 
URL https://www.sciencedirect.com/science/article/pii/S0928098722002457
 
URL https://doi.org/10.1016/j.ejps.2022.106360
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Opis:Background Uncontrolled pediatric asthma has a large impact on patients and their caregivers. More insight into determinants of uncontrolled asthma is needed. We aim to compare treatment regimens, inhaler techniques, medication adherence and other characteristics of children with controlled and uncontrolled asthma in the: Systems Pharmacology approach to uncontrolled Paediatric Asthma (SysPharmPediA) study. Material and methods 145 children with moderate to severe doctor-diagnosed asthma (91 uncontrolled and 54 controlled) aged 6–17 years were enrolled in this multicountry, (Germany, Slovenia, Spain, and the Netherlands) observational, case-control study. The definition of uncontrolled asthma was based on asthma symptoms and/or exacerbations in the past year. Patient-reported adherence and clinician-reported medication use were assessed, as well as lung function and inhalation technique. A logistic regression model was fitted to assess determinants of uncontrolled pediatric asthma. Results Children in higher asthma treatment steps had a higher risk of uncontrolled asthma (OR (95%CI): 3.30 (1.56–7.19)). The risk of uncontrolled asthma was associated with a larger change in FEV1% predicted post and pre-salbutamol (OR (95%CI): 1.08 (1.02–1.15)). Adherence and inhaler techniques were not associated with risk of uncontrolled asthma in this population. Conclusion This study showed that children with uncontrolled moderate-to-severe asthma were treated in higher treatment steps compared to their controlled peers, but still showed a higher reversibility response to salbutamol. Self-reported adherence and inhaler technique scores did not differ between controlled and uncontrolled asthmatic children. Other determinants, such as environmental factors and differences in biological profiles, may influence the risk of uncontrolled asthma in this moderate to severe asthmatic population.
Ključne besede:pediatric asthma, asthma control, uncontrolled asthma, medication, adherence, inhaler technique
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.02.2023
Leto izida:2023
Št. strani:str. 1-7
Številčenje:Vol. 181, article no.106360
PID:20.500.12556/DKUM-85022 Novo okno
UDK:616.2
COBISS.SI-ID:134636035 Novo okno
DOI:10.1016/j.ejps.2022.106360 Novo okno
ISSN pri članku:1879-0720
Datum objave v DKUM:16.08.2023
Število ogledov:472
Število prenosov:44
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
ALIZADEH BAHMANI, Amir Hossein, SLOB, Elise M. A., BLOEMSMA, Lizan D., BRANDSTETTER, Susanne, CORCUEREA, Paula, GORENJAK, Mario, HARNER, Susanne, HASHIMOTO, Simone, HEDMAN, Anna M., KABESCH, Michael in POTOČNIK, Uroš, 2023, Medication use in uncontrolled pediatric asthma : results from the SysPharmPediA study. European Journal of Pharmaceutical Sciences [na spletu]. 2023. Vol. 181,  106360, p. 1–7. [Dostopano 1 april 2025]. DOI 10.1016/j.ejps.2022.106360. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=85022
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Gradivo je del revije

Naslov:European Journal of Pharmaceutical Sciences
Založnik:Elsevier
ISSN:1879-0720
COBISS.SI-ID:23290117 Novo okno

Licence

Licenca:CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:astma, nadzor astme, nenadzorovana astma, zdravila


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