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Naslov:Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration
Avtorji:ID Naranđa, Jakob (Avtor)
ID Sušec, Maja (Avtor)
ID Maver, Uroš (Avtor)
ID Gradišnik, Lidija (Avtor)
ID Gorenjak, Mario (Avtor)
ID Vukasović, Andreja (Avtor)
ID Ivković, Alan (Avtor)
ID Rupnik, Marjan (Avtor)
ID Vogrin, Matjaž (Avtor)
ID Krajnc, Peter (Avtor)
Datoteke:.pdf Scientific_Reports_2016_Naranda_et_al._Polyester_type_polyHIPE_scaffolds_with_an_interconnected_porous_structure_for_cartilage_regenerat.pdf (1,24 MB)
MD5: A4B815E5AF0F76A50B6035FAB24FE2A6
 
URL http://www.nature.com/articles/srep28695
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Opis:Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication of polyHIPE polymer (PHP) was specifically tailored to produce a highly porous (85%) structure with the primary pore size in the range of 50–170 μm for cartilage tissue engineering. The resulting PHP scaffold was proven biocompatible with human articular chondrocytes and viable cells were observed within the materials as evaluated using the Live/Dead assay and histological analysis. Chondrocytes with round nuclei were organized into multicellular layers on the PHP surface and were observed to grow approximately 300 μm into the scaffold interior. The accumulation of collagen type 2 was detected using immunohistochemistry and chondrogenic specific genes were expressed with favorable collagen type 2 to 1 ratio. In addition, PHP samples are biodegradable and their baseline mechanical properties are similar to those of native cartilage, which enhance chondrocyte cell growth and proliferation.
Ključne besede:polyester, polymerization, polyHIPE
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Leto izida:2016
Št. strani:str. 1-11
Številčenje:Letn. 6
PID:20.500.12556/DKUM-66408 Novo okno
ISSN:2045-2322
UDK:66
COBISS.SI-ID:19662102 Novo okno
DOI:10.1038/srep28695 Novo okno
ISSN pri članku:2045-2322
NUK URN:URN:SI:UM:DK:7WJGSGNF
Datum objave v DKUM:23.06.2017
Število ogledov:1985
Število prenosov:415
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
NARANĐA, Jakob, SUŠEC, Maja, MAVER, Uroš, GRADIŠNIK, Lidija, GORENJAK, Mario, VUKASOVIĆ, Andreja, IVKOVIĆ, Alan, RUPNIK, Marjan, VOGRIN, Matjaž in KRAJNC, Peter, 2016, Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration. Scientific reports [na spletu]. 2016. Vol. 6, p. 1–11. [Dostopano 4 april 2025]. DOI 10.1038/srep28695. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=66408
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Gradivo je del revije

Naslov:Scientific reports
Skrajšan naslov:Sci. rep.
Založnik:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P2-0006
Naslov:Fizikalno kemijski pojavi na površinskih plasteh in uporaba nanodelcev

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:23.06.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:poliestri, polyHIPE, polimerizacija


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