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Naslov:Separation of peptides with forward osmosis biomimetic membranes
Avtorji:ID Bajraktari, Niada (Avtor)
ID Madsen, Henrik T. (Avtor)
ID Gruber, Mathias F. (Avtor)
ID Truelsen, Sigurd (Avtor)
ID Jensen, Elzbieta L. (Avtor)
ID Jensen, Henrik (Avtor)
ID Hélix-Nielsen, Claus (Avtor)
Datoteke:.pdf Membranes_2016_Bajraktari_et_al._Separation_of_Peptides_with_Forward_Osmosis_Biomimetic_Membranes.pdf (2,21 MB)
MD5: B6788AC93CD1CFF2C9CA62E2C2A62CD4
 
URL http://www.mdpi.com/2077-0375/6/4/46
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Opis:Forward osmosis (FO) membranes have gained interest in several disciplines for the rejection and concentration of various molecules. One application area for FO membranes that is becoming increasingly popular is the use of the membranes to concentrate or dilute high value compound solutions such as pharmaceuticals. It is crucial in such settings to control the transport over the membrane to avoid losses of valuable compounds, but little is known about the rejection and transport mechanisms of larger biomolecules with often flexible conformations. In this study, transport of two chemically similar peptides with molecular weight (Mw) of 375 and 692 Da across a thin film composite Aquaporin Inside™ Membrane (AIM) FO membrane was investigated. Despite the relative large size, both peptides were able to permeate the dense active layer of the AIM membrane and the transport mechanism was determined to be diffusion-based. Interestingly, the membrane permeability increased 3.65 times for the 692 Da peptide (1.39 × 10−12 m2·s−1) compared to the 375 Da peptide (0.38 × 10−12 m2·s−1). This increase thus occurs for an 85% increase in Mw but only for a 34% increase in peptide radius of gyration (Rg) as determined from molecular dynamics (MD) simulations. This suggests that Rg is a strong influencing factor for membrane permeability. Thus, an increased Rg reflects the larger peptide chains ability to sample a larger conformational space when interacting with the nanostructured active layer increasing the likelihood for permeation.
Ključne besede:forward osmosis, biomimetic, peptides, rejection
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Leto izida:2016
Št. strani:str. 1-12
Številčenje:Letn. 6, št. 4
PID:20.500.12556/DKUM-66338 Novo okno
ISSN:2077-0375
COBISS.SI-ID:21185046 Novo okno
DOI:10.3390/membranes6040046 Novo okno
ISSN pri članku:2077-0375
NUK URN:URN:SI:UM:DK:YA5YG3V2
Datum objave v DKUM:21.06.2017
Število ogledov:1184
Število prenosov:406
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
BAJRAKTARI, Niada, MADSEN, Henrik T., GRUBER, Mathias F., TRUELSEN, Sigurd, JENSEN, Elzbieta L., JENSEN, Henrik in HÉLIX-NIELSEN, Claus, 2016, Separation of peptides with forward osmosis biomimetic membranes. Membranes [na spletu]. 2016. Vol. 6, no. 4, p. 1–12. [Dostopano 20 januar 2025]. DOI 10.3390/membranes6040046. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=66338
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Gradivo je del revije

Naslov:Membranes
Skrajšan naslov:Membranes
Založnik:MDPI
ISSN:2077-0375
COBISS.SI-ID:519125529 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:direktna osmoza, biomimetika, peptidi, zavrnitev


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