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Naslov:Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties
Avtorji:ID Tomić, Sergej (Avtor)
ID Rudolf, Rebeka (Avtor)
ID Brunčko, Mihael (Avtor)
ID Anžel, Ivan (Avtor)
ID Savić, V. (Avtor)
ID Čolić, Miodrag (Avtor)
Datoteke:.pdf European_Cells_and_Materials_2012_Tomic_et_al._Response_of_monocyte-derived_dendritic_cells_to_rapidly_solidified_nickel-titanium_ribbon.pdf (1,35 MB)
MD5: 46D6B99513E650ADE5A0C66E33163A24
PID: 20.500.12556/dkum/8794315e-04c0-4719-a625-4e4aab07621e
 
URL http://www.ecmjournal.org/journal/papers/vol023/vol023a05.php
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FS - Fakulteta za strojništvo
Opis:Ni-Ti Shape Memory Alloys (SMAs) have attracted considerable attention as biomaterials for medical devices. However, the biocompatibility of Ni-Ti SMAs is often unsatisfactory due to their poor surface structure. Here we prepared Rapidly Solidified (RS) Ni-Ti SMA ribbons by melt-spinning and their surface was characterised by Augerelectron spectroscopy, X-ray photoelectron spectrometry and scanning electron microscopy. The biocompatibility of the produced ribbons and their immunomodulatory properties were studied on human monocyte-derived dendritic cells (MoDCs). We showed that melt-spinning of Ni-Ti SMAs can form a thin homogenous oxide layer, which improves their corrosion resistance and subsequent toxicity to MoDCs. Ni-Ti RS ribbons stimulated the maturation of MoDCs, as detected by changes in the cells' morphology and increased expression of HLA-DR, CD86, CD40 and CD83 molecules. However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-β-producing CD4+T cells. On the other hand, in the presence of lipopolysaccharide, an important pro-inflammatory biomolecule, Ni-Ti RS ribbons enhanced the allostimulatory and Th1 polarising capacity of MoDCs, whereas the production of Th2 and Th17 cytokines was down-regulated. In conclusion, Ni-Ti RS ribbons possess substantial immunomodulatory properties on MoDCs. These findings might be clinically relevant, because implanted Ni-Ti SMA devices can induce both desired and adverse effects on the immune system, depending on the microenvironmental stimuli.
Ključne besede:nickel-titanium alloy, biocompatibility, cytokines, immunomodulation, monocyte-derived dendritic cells
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Leto izida:2012
Št. strani:str. 58-80
Številčenje:Letn. 23
PID:20.500.12556/DKUM-27240-d1276669-88df-d96d-7735-8604d2a7f30a Novo okno
ISSN:1473-2262
UDK:669:61
COBISS.SI-ID:15705366 Novo okno
DOI:10.22203/eCM.v023a05 Novo okno
ISSN pri članku:1473-2262
NUK URN:URN:SI:UM:DK:PQFJBRAW
Datum objave v DKUM:01.06.2012
Število ogledov:2084
Število prenosov:378
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
TOMIĆ, Sergej, RUDOLF, Rebeka, BRUNČKO, Mihael, ANŽEL, Ivan, SAVIĆ, V. in ČOLIĆ, Miodrag, 2012, Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties. European Cells & Materials [na spletu]. 2012. Vol. 23, p. 58–80. [Dostopano 17 marec 2025]. DOI 10.22203/eCM.v023a05. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=27240
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Gradivo je del revije

Naslov:European Cells & Materials
Skrajšan naslov:Eur. Cells Mater.
Založnik:AO Research Institute Davos
ISSN:1473-2262
COBISS.SI-ID:4545306 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:nikelj-titanova zlitina, biokompatibilnost, citokini, imunomodulacija, monocitne dendritične celice


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