Spatial network representation of complex living tissues

Korošak, Dean; Rupnik, Marjan

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Naslov:	Spatial network representation of complex living tissues
Avtorji:	ID Korošak, Dean (Avtor) ID Rupnik, Marjan (Avtor)
Datoteke:	http://dx.doi.org/10.1063/1.3046243
Jezik:	Angleški jezik
Vrsta gradiva:	Neznano
Tipologija:	1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:	FGPA - Fakulteta za gradbeništvo, prometno inženirstvo in arhitekturo
Opis:	Networks were widely used to describe organizational and functional principles of living organisms across various scales. The topology of such biological complex networks often turned out to be "scale-free", with the power-law distribution of number of links per node, robust and modular with underlying self-similar structure. However, the topology of cytoarchitecture in living tissues has not yet received wide attention from the network perspective. Here we discuss the spatial complex network model of coupled clusters of beta cells in pancreatic islets. Networks of cells in pancreatic islets were constructed from the 2D section images presenting fluorescently labelled intercellular spaces obtained by two-photon laser scanning microscopy of whole pancreas tissue slices, and cells conductances measured electrophysiologically using whole-cell patch-clamp. We find that the heterogeneity of beta cells in intact living islets induces scale-free topology of the tissue network. Furthermore, we show that the islet-like structures visually similar to 2D section images can be obtained using Voronoi diagrams of random points.
Ključne besede:	pancreatic islets, betta cells, complex networks, cytoarchitecture
Leto izida:	2008
PID:	20.500.12556/DKUM-26332
UDK:	530.1:007.52
COBISS.SI-ID:	12892694
NUK URN:	URN:SI:UM:DK:H30CGTTJ
Datum objave v DKUM:	31.05.2012
Število ogledov:	2255
Število prenosov:	81
Metapodatki:
Področja:	Ostalo
:	KOROŠAK, Dean in RUPNIK, Marjan, 2008, Spatial network representation of complex living tissues. V : [na spletu]. Objavljeni znanstveni prispevek na konferenci. 2008. [Dostopano 22 marec 2025]. Pridobljeno s: http://dx.doi.org/10.1063/1.3046243 Kopiraj citat

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