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Title:Targeting cardiovascular risk factors through dietary adaptations and caloric restriction mimetics
Authors:ID Voglhuber, Julia (Author)
ID Ljubojevic-Holzer, Senka (Author)
ID Abdellatif, Mahmoud (Author)
ID Sedej, Simon (Author)
Files:.pdf Voglhuber-2021-Targeting_Cardiovascular_Risk_F.pdf (1,14 MB)
MD5: 9F684E98AF83231205F79BBFD26D1E2B
 
URL https://doi.org/10.3389/fnut.2021.758058
 
Language:English
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:The average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, obesity, diabetes mellitus, and metabolic syndrome. However, low adherence to caloric restriction renders this stringent dietary intervention challenging to adopt as a standard practice for cardiovascular disease prevention. Hence, alternative eating patterns and strategies that recapitulate the salutary benefits of caloric restriction are under intense investigation. Here, we first provide an overview of alternative interventions, including intermittent fasting, alternate-day fasting and the Mediterranean diet, along with their cardiometabolic effects in animal models and humans. We then present emerging pharmacological alternatives, including spermidine, NAD+ precursors, resveratrol, and metformin, as promising caloric restriction mimetics, and briefly touch on the mechanisms underpinning their cardiometabolic and health-promoting effects. We conclude that implementation of feasible dietary approaches holds the promise to attenuate the burden of cardiovascular disease and facilitate healthy aging in humans.
Keywords:autophagy, caloric restriction, caloric restriction mimetics, cardiovascular risk factors, dietary regimens, hypertension, intermittent fasting, obesity
Publication status:Published
Publication version:Version of Record
Submitted for review:13.08.2021
Article acceptance date:07.09.2021
Publication date:30.09.2021
Publisher:Frontiers
Year of publishing:2021
Number of pages:Str. 1-17
Numbering:Letn. 8, št. članka 758058
PID:20.500.12556/DKUM-91086 New window
UDC:616.1:613.2
ISSN on article:2296-861X
COBISS.SI-ID:130726403 New window
DOI:10.3389/fnut.2021.758058 New window
Publication date in DKUM:21.10.2024
Views:0
Downloads:2
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
VOGLHUBER, Julia, LJUBOJEVIC-HOLZER, Senka, ABDELLATIF, Mahmoud and SEDEJ, Simon, 2021, Targeting cardiovascular risk factors through dietary adaptations and caloric restriction mimetics. Frontiers in nutrition [online]. 2021. Vol. 8, no. članka 758058, p. 1–17. [Accessed 14 March 2025]. DOI 10.3389/fnut.2021.758058. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=91086
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Record is a part of a journal

Title:Frontiers in nutrition
Shortened title:Front. nutr.
Publisher:Frontiers Media S.A.
ISSN:2296-861X
COBISS.SI-ID:4431992 New window

Document is financed by a project

Funder:FWF - Austrian Science Fund
Project number:I3301
Funder:Other - Other funder or multiple funders
Name:European Research Area Network on Cardiovascular disease
Acronym:ERA-CVD, MINOTAUR
Funder:FWF - Austrian Science Fund
Project number:V530
Funder:Other - Other funder or multiple funders

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:30.09.2021

Secondary language

Language:Slovenian
Keywords:avtofagija, omejitev kalorij, mimetiki omejevanja kalorij, dejavniki tveganja za bolezni srca in ožilja, dietni režimi, hipertenzija, prekinitveno stradanje, debelost


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