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Title:In vitro disease models of the endocrine pancreas
Authors:ID Milojević, Marko (Author)
ID Rožanc, Jan (Author)
ID Vajda, Jernej (Author)
ID Činč Ćurić, Laura (Author)
ID Paradiž, Eva (Author)
ID Stožer, Andraž (Author)
ID Maver, Uroš (Author)
ID Vihar, Boštjan (Author)
Files:.pdf Milojevic-2021-In_Vitro_Disease_Models_of_the.pdf (4,42 MB)
MD5: E23A5CF9D6A3374527D9B65F00E15457
 
URL https://doi.org/10.3390/biomedicines9101415
 
Language:English
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:The ethical constraints and shortcomings of animal models, combined with the demand to study disease pathogenesis under controlled conditions, are giving rise to a new field at the interface of tissue engineering and pathophysiology, which focuses on the development of in vitro models of disease. In vitro models are defined as synthetic experimental systems that contain living human cells and mimic tissue- and organ-level physiology in vitro by taking advantage of recent advances in tissue engineering and microfabrication. This review provides an overview of in vitro models and focuses specifically on in vitro disease models of the endocrine pancreas and diabetes. First, we briefly review the anatomy, physiology, and pathophysiology of the human pancreas, with an emphasis on islets of Langerhans and beta cell dysfunction. We then discuss different types of in vitro models and fundamental elements that should be considered when developing an in vitro disease model. Finally, we review the current state and breakthroughs in the field of pancreatic in vitro models and conclude with some challenges that need to be addressed in the future development of in vitro models.
Keywords:in vitro disease models, pancreas, islet of Langerhans, 3D cell culture, scaffolds, acute tissue slices
Publication status:Published
Publication version:Version of Record
Submitted for review:01.09.2021
Article acceptance date:05.10.2021
Publication date:08.10.2021
Publisher:MDPI
Year of publishing:2021
Number of pages:Str. 1-34
Numbering:Letn. 9, Št. 10, št. članka 1415
PID:20.500.12556/DKUM-90865 New window
UDC:612.34
ISSN on article:2227-9059
COBISS.SI-ID:81293571 New window
DOI:10.3390/biomedicines9101415 New window
Publication date in DKUM:01.10.2024
Views:0
Downloads:391
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
MILOJEVIĆ, Marko, ROŽANC, Jan, VAJDA, Jernej, ČINČ ĆURIĆ, Laura, PARADIŽ, Eva, STOŽER, Andraž, MAVER, Uroš and VIHAR, Boštjan, 2021, In vitro disease models of the endocrine pancreas. Biomedicines [online]. 2021. Vol. 9, no. Št. 10,  članka 1415, p. 1–34. [Accessed 17 April 2025]. DOI 10.3390/biomedicines9101415. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=90865
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Record is a part of a journal

Title:Biomedicines
Shortened title:Biomedicines
Publisher:MDPI AG
ISSN:2227-9059
COBISS.SI-ID:523006745 New window

Document is financed by a project

Funder:MIZŠ - Slovene Ministry of Science, Education, and Sport
Project number:C3330-19-952028
Funder:MIZŠ - Slovene Ministry of Science, Education, and Sport
Project number:C3330-19-952029
Funder:ARRS - Slovenian Research Agency
Project number:P3-0036
Name:Bio-psiho-socialni model kvalitete življenja
Funder:ARRS - Slovenian Research Agency
Project number:I0-0029
Name:Infrastrukturna dejavnost Univerze v Mariboru
Funder:ARRS - Slovenian Research Agency
Project number:L4-1843
Name:Inovativni afinitetni sistem za ločevanje populacij krvnih celic
Funder:ARRS - Slovenian Research Agency
Project number:J3-2538
Name:Strategija za izboljšanje kvalitete življenja in ortopedskega zdravljenja hrustančnih poškodb - Napredni 3D (bio)tiskani nosilci za tkivno regeneracijo
Funder:ARRS - Slovenian Research Agency
Project number:N3-0133
Name:Celice beta med razvojem in remisijo z dieto povzročene sladkorne bolezni
Funder:ARRS - Slovenian Research Agency
Project number:J3-9289
Name:Vloga cikličnega adenozin monofosfata v normalni fiziologiji celic beta in med razvojem sladkorne bolezni tipa 2
Funder:ARRS - Slovenian Research Agency
Project number:N3-0048
Name:Vloga ionskih kanalov TRPM3 in TRPM5 pri uravnavanju mrežne aktivnosti v otočkih trebušne slinavke
Funder:ARRS - Slovenian Research Agency
Project number:P3-0396
Name:Celične in tkivne mreže
Funder:Other - Other funder or multiple funders
Funding programme:Young Researcher Program

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:08.10.2021

Secondary language

Language:Slovenian
Keywords:in vitro modeli bolezni, trebušna slinavka, Langerhansovi otočki, 3D celična kultura, ogrodja, rezine akutnega tkiva


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