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Title:Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief
Authors:ID Zidarič, Tanja (Author)
ID Skok, Kristijan (Author)
ID Orthaber, Kristjan (Author)
ID Pristovnik, Matevž (Author)
ID Gradišnik, Lidija (Author)
ID Maver, Tina (Author)
ID Maver, Uroš (Author)
Files:.pdf Zidaric-2023-Multilayer_Methacrylate-Based_Wou.pdf (1,61 MB)
MD5: 01C6E305C1E5492519547215E7897E20
 
URL https://doi.org/10.3390/ma16062361
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.
Keywords:wound dressings, pain relief, superparamagnetic nanoparticles, methacrylate
Publication status:Published
Publication version:Version of Record
Submitted for review:01.03.2023
Article acceptance date:13.03.2023
Publication date:15.03.2023
Publisher:MDPI
Year of publishing:2023
Number of pages:Str. 1-21
Numbering:Letn. 16, Št. 6, št. članka 2361
PID:20.500.12556/DKUM-88404 New window
UDC:615.4
ISSN on article:1996-1944
COBISS.SI-ID:146598147 New window
DOI:10.3390/ma16062361 New window
Publication date in DKUM:19.04.2024
Views:485
Downloads:469
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
ZIDARIČ, Tanja, SKOK, Kristijan, ORTHABER, Kristjan, PRISTOVNIK, Matevž, GRADIŠNIK, Lidija, MAVER, Tina and MAVER, Uroš, 2023, Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief. Materials [online]. 2023. Vol. 16, no. Št. 6,  članka 2361, p. 1–21. [Accessed 30 March 2025]. DOI 10.3390/ma16062361. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=88404
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Record is a part of a journal

Title:Materials
Shortened title:Materials
Publisher:MDPI
ISSN:1996-1944
COBISS.SI-ID:33588485 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:J3-1762
Name:Nov inovativen pristop k zdravljenju pleničnega izpuščaja z uporabo plenic z vgrajenimi probiotičnimi bakterijami
Funder:ARRS - Slovenian Research Agency
Project number:P3-0036
Name:Bio-psiho-socialni model kvalitete življenja
Funder:ARRS - Slovenian Research Agency
Project number:I0-0029
Name:Infrastrukturna dejavnost Univerze v Mariboru
Funder:ARRS - Slovenian Research Agency
Project number:L7-4494
Name:Kompleksen in vitro model kože z vključeno plastjo kosti za testiranje ne-invazivnega glukoznega senzorja
Funder:Other - Other funder or multiple funders
Funding programme:Ministry for Education, Science, and Sport
Project number:C3330-19-952027

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:15.03.2023

Secondary language

Language:Slovenian
Keywords:obloge za rane, lajšanje bolečin, superparamagnetni nanodelci, metakrilat


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