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Title:Ocena epikardialnega maščevja in karotidnih arterij z magnetno resonanco pri otrocih s primarno arterijsko hipertenzijo
Authors:ID Schweighofer, Nina (Author)
ID Kanič, Vojko (Mentor) More about this mentor... New window
Files:.pdf DOK_Schweighofer_Nina_2023.pdf (3,15 MB)
MD5: 6DCFE3592F55091862F46A5CB3A32664
 
Language:Slovenian
Work type:Doctoral dissertation
Typology:2.08 - Doctoral Dissertation
Organization:MF - Faculty of Medicine
Abstract:Epikardialno maščevje je presnovno aktivno maščobno tkivo, ki se nahaja neposredno na površini miokarda. Epikardialno maščevje izloča bioaktivne molekule in ima potencialno vlogo pri razvoju primarne arterijske hipertenzije že v zgodnjem starostnem obdobju. S prospektivno magnetnoresonančno študijo smo primerjali volumen in debelino epikardialnega maščevja ter debelino intime medije pri otrocih in mladostnikih s primarno arterijsko hipertenzijo in pri zdravih kontrolah. Ugotovili smo, da imajo otroci s povišanim krvnim tlakom večji volumen in večjo debelino epikardialnega maščevja, ob tem pa tudi višjo debelino intime medije od zdravih vrstnikov. Vse spremenljivke kažejo pozitivno medsebojno korelacijo. Naš model je pokazal, da povečanje volumna epikardialnega maščevja za en 1 cm3 pomeni 9,5-krat večjo verjetnost za razvoj primarne arterijske hipertenzije pri otrocih in mladostnikih. Izmed vseh izbranih parametrov s hipertenzijo pri otrocih in mladostnikih najbolje korelira volumen epikardialnega maščevja. Sklepamo lahko, da je le-ta izmed izbranih dejavnikov najboljši napovedni dejavnik za možnost prisotnosti primarne arterijske hipertenzije pri otrocih in mladostnikih.
Keywords:epikardialno maščevje, otroci in mladostniki, arterijska hipertenzija, magnetna resonanca srca, ultrazvok
Place of publishing:Maribor
Year of publishing:2023
PID:20.500.12556/DKUM-84013 New window
COBISS.SI-ID:182078211 New window
Publication date in DKUM:31.01.2024
Views:317
Downloads:30
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:MF
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:28.03.2023

Secondary language

Language:English
Title:Evaluation of epicardial adipose tissue and carotid arteries with magnetic resonance in children with essential arterial hypertension
Abstract:Epicardial adipose tissue is a metabolically active adipose tissue depot located directly on the surface of the myocardium. Epicardial adipose tissue secrets bioactive molecules and has a potential role in developing primary arterial hypertension at a very young age. In a prospective magnetic-resonance study, we evaluated the volume and thickness of epicardial adipose tissue and intima-media thickness in children and adolescents with elevated blood pressure and compared them with their healthy peers. Hypertensive patients have higher volume and thickness of epicardial adipose tissue and higher intima-media thickness compared to their healthy peers. All of the variables show a positive correlation. Our model shows that increasing epicardial adipose tissue volume for 1 cm3 results in a 9,5-times higher probability of developing hypertension. Out of all selected variables, the epicardial adipose tissue volume shows the best correlation with hypertension. We can conclude that epicardial adipose tissue is the best prognostic factor for the probability of arterial hypertension in children and adolescents.
Keywords:epicardial adipose tissue, children and adolescents, arterial hypertension, cardiac magnetic resonance imaging, ultrasound


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