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Title:
Potencial kurkumina v klinični uporabi
Authors:
ID
Brumec, Timotej
(Author)
ID
Fajmut, Aleš
(Mentor)
More about this mentor...
Files:
MAG_Brumec_Timotej_2020.pdf
(1012,00 KB)
MD5: C4A2A9DAD222A94831F0136F612C100C
PID:
20.500.12556/dkum/1e99243d-533f-4a52-ad4f-fa435194f14d
Language:
Slovenian
Work type:
Master's thesis/paper
Typology:
2.09 - Master's Thesis
Organization:
FZV - Faculty of Health Sciences
Abstract:
V magistrskem delu smo predstavili rastlino kurkumo in njeno učinkovino kurkumin. Sama rastlina kurkuma (Curcuma longa) uspeva na Indijskem polotoku in jugovzhodni Aziji ter se že izredno dolgo uporablja v ajurvedski medicini za zdravljenje vnetnih bolezni. Številne moderne študije so pokazale pozitivne učinke kurkumina pri mnogih bolezenskih stanjih, kot so: rak, ulcerozni kolitis, revmatoidni artritis, pankreatitis, osteoartritis in številnih drugih. Največja težava pri uporabi kurkumina za zdravljenje v moderni medicini je njegova slaba biorazpoložljivost, saj so v krvni plazmi zaznali zelo majhne koncentracije kurkumina tudi ob zaužitju večjih doz. V sami nalogi smo predstavili več bolezenskih stanj, katera bi naj kurkumin izboljšal, ter študije oziroma raziskave, v katerih so te učinke kurkumina dokazali. Prav tako smo prej omenjene študije med seboj tudi primerjali. Delovanje kurkumina izhaja iz njegove sposobnosti vplivanja na veliko število signalnih molekul, kot so: pro-inflamatorni citokini, encimi, apoptozni proteini, adhezijske molekule, nuklearni faktorji in ostale. Nepravilno delovanje prej naštetih molekul in signalnih poti, v katerih te molekule sodelujejo, so mnoge študije povezale z razvojem raznih bolezenskih stanj. V nadaljevanju smo podrobneje pregledali spletno bazo PubMed. Z dodajanjem drugih ključnih besed smo raziskovalni vzorec postopoma omejevali. Osredotočali smo se na število študij, ki so bile izvedene in vivo ali pa in vitro, prav tako smo se osredotočali tudi na število študij, ki so se izvedle v kliničnem okolju.
Keywords:
kurkuma
,
ajurvedska medicina
,
signalne poti
,
klinične študije
,
nutracevtiki.
Place of publishing:
Maribor
Publisher:
[T. Brumec]
Year of publishing:
2020
PID:
20.500.12556/DKUM-75859
UDC:
633.826:615.03(043.2)
COBISS.SI-ID:
19024899
NUK URN:
URN:SI:UM:DK:VEHD97MI
Publication date in DKUM:
11.06.2020
Views:
1343
Downloads:
191
Metadata:
Categories:
FZV
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:
BRUMEC, Timotej, 2020,
Potencial kurkumina v klinični uporabi
[online]. Master’s thesis. Maribor : T. Brumec. [Accessed 21 January 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=75859
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Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
20.02.2020
Secondary language
Language:
English
Title:
The potential of curcumin in clinical use
Abstract:
In this master thesis the plant Turmeric and its main constituent, curcumin has been thoroughly described. The plant Turmeric (Curcuma longa) is native to the Indian subcontinent and Southeast Asia and has a long history of use in the Ayurvedic medicine. Numerous studies have shown the positive effects of curcumin on different pathological conditions, such as cancer, ulcerative colitis, rheumatoid arthritis, pancreatitis, osteoarthritis and many other. What hinders the medicinal use of curcumin the most is its low bioavailability, since extremely low levels have been detected in blood plasma even after administering very high doses. In the thesis many different pathological conditions will be described, on which curcumin is supposed to have beneficial effects. We focused on various studies, who claim to have proved these beneficial effects. These aforementioned studies have also be compared with one another. Curcumin is capable of having an effect on many signalling molecules, such as pro-inflammatory cytokines, enzymes, apoptotic proteins, prostaglandins, cell adhesion molecules, NF–κB, COX-2, STAT3 and others. Irregularities in aforementioned molecules and signalling pathways have been linked to countless pathological conditions by numerous studies. In the following chapters we took a closer look at the online database PubMed. We were periodically narrowing our search by adding additional keywords, thus focusing ourselves on the number of studies, that had been carried out either in vivo or in vitro. We also focused on the number of studies, carried out in a clinical environment.
Keywords:
turmeric
,
ayurvedic medicine
,
signalling pathways
,
clinical studies
,
nutraceuticals.
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