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Title:
Numerical analysis of fluid flow in a vial : [master thesis]
Authors:
ID
Časar, Žiga
(Author)
ID
Hriberšek, Matjaž
(Mentor)
More about this mentor...
ID
Zadravec, Matej
(Comentor)
Files:
MAG_Casar_Ziga_2019.pdf
(2,66 MB)
MD5: 6BD3F418EBC728459BAFAF5F82B0CB36
PID:
20.500.12556/dkum/aaa2988b-2428-4364-ba0a-3d0bd895e6f5
Language:
English
Work type:
Master's thesis/paper
Typology:
2.09 - Master's Thesis
Organization:
FS - Faculty of Mechanical Engineering
Abstract:
Lyophilization or freeze-drying is a widely used process in the pharmaceutical and food industry. In the process the solvent will be removed under extreme conditions of low temperature and low system pressures, whereby sublimation happens, the transition from the solid phase to the gas phase, with skipping the liquid phase, which happens bellow the triple point. This study focuses on numerical modeling at the start of the process, the so called primary drying. For this stage the highest mass flow rates of vapor are typical, since the driving force of the process is the pressure difference between the sublimation front and surrounding area. In this stage the non-bonded solvent is removed. Because of the extreme conditions the typical computational fluid dynamics approach is not suitable anymore and has to be corrected. One way to do this is to use additional models for fluid behavior at the solid wall. The study focuses on the influence of different boundary conditions on the solid wall, No-Slip, Free Slip and Maxwell Slip, and their effect on fluid flow inside the vial. A quantitative and qualitative comparison of the results is presented.
Keywords:
Lyophilization
,
Knudsen number
,
computational fluid dynamics
,
fluid flow
,
numerical modeling
,
slip boundary condition
Place of publishing:
Maribor
Place of performance:
Maribor
Publisher:
[Ž. Časar]
Year of publishing:
2019
Number of pages:
VIII, 34 str.
PID:
20.500.12556/DKUM-73861
UDC:
004.414.23:57.086.13(043.2)
COBISS.SI-ID:
22769686
NUK URN:
URN:SI:UM:DK:DRN7IHG7
Publication date in DKUM:
09.07.2019
Views:
1570
Downloads:
204
Metadata:
Categories:
KTFMB - FS
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:
ČASAR, Žiga, 2019,
Numerical analysis of fluid flow in a vial : [master thesis]
[online]. Master’s thesis. Maribor : Ž. Časar. [Accessed 25 March 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=73861
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Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:
22.06.2019
Secondary language
Language:
Slovenian
Title:
Numerična analiza tokovnih razmer v viali
Abstract:
Izdelki v farmacevtski in prehrambni industriji so zaradi svoje kemijske sestave pogosto občutljivi na visoke temperature, zaradi česar je potrebno z njimi ravnati drugače, kot z običajnimi materiali. V primeru kadar je potrebno izdelke sušiti, torej odstraniti topilo iz že obstoječe zmesi, se posega po procesu liofilizacije. Liofilizacija je proces odstranjevanja topila iz zamrznjene zmesi, pri čemer pride do faznega prehoda iz trdnine v plin (sublimacija), kar pa je mogoče izvesti pri zelo nizkih temperaturah in obratovalnih tlakih. Gonilna sila procesa je tlačna razlika med uparjalno fronto in okolico. Nanjo vplivajo predvsem tokovne razmere v okolici, geometrija in prenos toplote znotraj liofilizatorja. Z dobrim poznavanjem vseh dejavnikov je mogoče proces dodatno optimirati in s tem zagotoviti željen rezultat.
Keywords:
Liofilizacija
,
Knudsenovo število
,
računalniška dinamika tekočin
,
tokovne razmere
,
numerično modeliranje
,
robni pogoj zdrsa
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