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Title:Razvoj naprednih medicinskih tekstilij z uporabo izbranih polifenolov in polisaharidov
Authors:Petek, Gabrijela (Author)
Fras Zemljič, Lidija (Mentor) More about this mentor... New window
Anžel, Ivan (Co-mentor)
Peršin, Zdenka (Co-mentor)
Files:.pdf MAG_Petek_Gabrijela_2018.pdf (5,49 MB)
MD5: 465E423CF17FDB2E4E90305DB86E3FA0
 
Language:Slovenian
Work type:Master's thesis/paper (mb22)
Typology:2.09 - Master's Thesis
Organization:FS - Faculty of Mechanical Engineering
Abstract:Trend razvoja medicinskih tekstilnih materialov za zdravljenje in celjenje ran, temelji na uporabi materialov, ki so pripravljeni na osnovi naravnih učinkovin z bioaktivnimi lastnostmi. Tradicionalno oskrbo ran je zamenjala uporaba sodobnih oblog, med katerimi je v zadnjem času zlasti privlačna priprava nanovlaknastih materialov. V magistrski nalogi smo se osredotočili na pripravo naprednih medicinskih tekstilij na osnovi hitozana, ki smo jih izdelali s postopkom elektropredenja. Tako izdelane tekstilije so zaradi velike gostote por, velikega razmerja med specifično površino in volumnom, visoke prepustnosti ter majhnega premera vlaken, primerna za sproščanje učinkovin. V našem primeru smo uporabili učinkovini katehin in resveratrol, ki s svojim antioksidativnim značajem ugodno vplivata na celjenje ran. Tekoče formulacije smo pripravili po postopku ionotropnega geliranja, ter tako izbrano učinkovino ujeli v hitozanske nanodelce. Karakterizacija pripravljenih disperzij hitozanskih nanodelcev z ujetimi polifenoli je potekala na podlagi določevanja velikosti delcev (DLS) ter vrednotenja antioksidativne in protimikrobne učinkovitosti. Iz pripravljenih tekočih formulacij smo s postopkom elektropredenja pripravili kompozitne vzorce medicinskih tekstilij, pri čemer je bilo potrebno postopek elektropredenja optimizirati s strani predilne raztopine ter parametrov predenja. Z uporabo Fourier transformirane infrardeče spektroskopije (FTIR), vrstične elektronske spektroskopije (SEM) in rentgenske fotoelektronske spektroskopije (XPS) smo pripravljene materiale okarakterizirali z fizikalno-kemijskega vidika ter ovrednotili učinek antioksidativnosti in protimikrobnosti. Na koncu smo izvedli analizo in vitro sproščanja učinkovin. Dokazali smo, da so tako pripravljeni kompozitni materiali multifunkcionalni z vidika bioaktivnosti, saj izkazujejo protimikrobne in antioksidativne lastnosti. Hkrati omogočajo tudi kontrolirano sproščanje učinkovin, s čimer izkazujejo potencial za uporabo v medicinskih aplikacijah, predvsem na področju zdravljenja in celjenja ran.
Keywords:medicinske tekstilije, hitozan, katehin, resveratrol, elektropredenje, nanovlakna, DLS, FTIR, SEM, XPS, antioksidativnost, protimikrobno testiranje, in vitro sproščanje
Year of publishing:2018
Publisher:[G. Petek]
Source:Maribor
UDC:677.017.86:615.4(043.2)
COBISS_ID:22145814 New window
NUK URN:URN:SI:UM:DK:5L5CAUYB
Views:528
Downloads:86
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:KTFMB - FS
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:24.05.2018

Secondary language

Language:English
Title:Development of medical textiles using polyphenols and polysaccharides
Abstract:Development trend of medical textiles for the wound treatment and wound healing represents the use of the materials, which are prepared from natural substances with bioactive properties. Traditional wound care has been replaced by the use of modern wound dressings among which are recently especially attractive nanofiberous materials. In this master’s work, we focused on the preparation of the advanced medical textiles, made from chitosan via electrospinning process. So prepared materials are due to high porosity of structure, high specific surface area to volume ratio, a high permeability and small fiber diameter, suitable for the release of the substances. We used catechin and resveratrol because of their antioxidative character, which favorably affect to the wound healing process. Liquid formulation were prepared by ionoic gelation method according to which catechin and resveratrol were encapsulated in chitosan nanoparticles. Nanoparticles based formulations were characterized by determination of the particle size (DLS) and evaluation of antioxidant and antimicrobial efficiency. Composite medical textiles samples were prepared by electrospinning process from the prepared liquid formulation. From the standpoint of used spinning solution and spinning parameter was process optimized. With Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were prepared samples characterized. We also evaluated antioxidative and antimicrobial properties of functionalized materials. At the end, we performed the analysis of the in vitro release. It was proven that prepared materials are bioactive, because of their antimicrobial and antioxidant properties. At the same time, prepared medical textiles also enable release of the substances. They show potential for use in medical applications, in particular for the wound treatment and wound healing.
Keywords:medical textiles, chitosan, catechin, resveratrol, electrospinning, nanofibers, DLS, FTIR, SEM, XPS, antioxidativity, antimicrobial testing, in vitro release


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