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Title:Regulation of irregular neuronal firing by autaptic transmission
Authors:ID Guo, Daqing (Author)
ID Wu, Shengdun (Author)
ID Chen, Mingming (Author)
ID Perc, Matjaž (Author)
ID Zhang, Yangsong (Author)
ID Ma, Jingling (Author)
ID Cui, Yan (Author)
ID Xu, Peng (Author)
ID Xia, Yang (Author)
ID Yao, Dezhong (Author)
Files:.pdf Scientific_Reports_2016_Guo_et_al._Regulation_of_Irregular_Neuronal_Firing_by_Autaptic_Transmission.pdf (2,65 MB)
MD5: 4CB28F503AABD37E79B6A3282E85FF3C
 
URL http://www.nature.com/articles/srep26096
 
Language:English
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics.
Keywords:neuronal dynamics, autapse, regulation, excitation
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:str. 1-14
Numbering:Letn. 6
PID:20.500.12556/DKUM-66409 New window
ISSN:2045-2322
UDC:53
ISSN on article:2045-2322
COBISS.SI-ID:22210568 New window
DOI:10.1038/srep26096 New window
NUK URN:URN:SI:UM:DK:8NOX4XBV
Publication date in DKUM:23.06.2017
Views:1306
Downloads:423
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
GUO, Daqing, WU, Shengdun, CHEN, Mingming, PERC, Matjaž, ZHANG, Yangsong, MA, Jingling, CUI, Yan, XU, Peng, XIA, Yang and YAO, Dezhong, 2016, Regulation of irregular neuronal firing by autaptic transmission. Scientific reports [online]. 2016. Vol. 6, p. 1–14. [Accessed 20 January 2025]. DOI 10.1038/srep26096. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=66409
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Record is a part of a journal

Title:Scientific reports
Shortened title:Sci. rep.
Publisher:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:23.06.2017

Secondary language

Language:Slovenian
Keywords:nevronska dinamika, avtapsa, regulacija, eksitacije


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