| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font
First page > Show document

Show document Help

Title:Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration
Authors:ID Naranđa, Jakob (Author)
ID Sušec, Maja (Author)
ID Maver, Uroš (Author)
ID Gradišnik, Lidija (Author)
ID Gorenjak, Mario (Author)
ID Vukasović, Andreja (Author)
ID Ivković, Alan (Author)
ID Rupnik, Marjan (Author)
ID Vogrin, Matjaž (Author)
ID Krajnc, Peter (Author)
Files:.pdf Scientific_Reports_2016_Naranda_et_al._Polyester_type_polyHIPE_scaffolds_with_an_interconnected_porous_structure_for_cartilage_regenerat.pdf (1,24 MB)
MD5: A4B815E5AF0F76A50B6035FAB24FE2A6
 
URL http://www.nature.com/articles/srep28695
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication of polyHIPE polymer (PHP) was specifically tailored to produce a highly porous (85%) structure with the primary pore size in the range of 50–170 μm for cartilage tissue engineering. The resulting PHP scaffold was proven biocompatible with human articular chondrocytes and viable cells were observed within the materials as evaluated using the Live/Dead assay and histological analysis. Chondrocytes with round nuclei were organized into multicellular layers on the PHP surface and were observed to grow approximately 300 μm into the scaffold interior. The accumulation of collagen type 2 was detected using immunohistochemistry and chondrogenic specific genes were expressed with favorable collagen type 2 to 1 ratio. In addition, PHP samples are biodegradable and their baseline mechanical properties are similar to those of native cartilage, which enhance chondrocyte cell growth and proliferation.
Keywords:polyester, polymerization, polyHIPE
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:str. 1-11
Numbering:Letn. 6
PID:20.500.12556/DKUM-66408 New window
ISSN:2045-2322
UDC:66
ISSN on article:2045-2322
COBISS.SI-ID:19662102 New window
DOI:10.1038/srep28695 New window
NUK URN:URN:SI:UM:DK:7WJGSGNF
Publication date in DKUM:23.06.2017
Views:1985
Downloads:416
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
NARANĐA, Jakob, SUŠEC, Maja, MAVER, Uroš, GRADIŠNIK, Lidija, GORENJAK, Mario, VUKASOVIĆ, Andreja, IVKOVIĆ, Alan, RUPNIK, Marjan, VOGRIN, Matjaž and KRAJNC, Peter, 2016, Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration. Scientific reports [online]. 2016. Vol. 6, p. 1–11. [Accessed 23 April 2025]. DOI 10.1038/srep28695. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=66408
Copy citation
  
Average score:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Scientific reports
Shortened title:Sci. rep.
Publisher:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P2-0006
Name:Fizikalno kemijski pojavi na površinskih plasteh in uporaba nanodelcev

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:23.06.2017

Secondary language

Language:Slovenian
Keywords:poliestri, polyHIPE, polimerizacija


Comments

Leave comment

You must log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back
Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica