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Title:Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications
Authors:ID Finšgar, Matjaž (Author)
ID Perva, Amra (Author)
ID Stergar, Janja (Author)
ID Gradišnik, Lidija (Author)
ID Maver, Uroš (Author)
Files:.pdf Scientific_Reports_2016_Finsgar_et_al._Novel_chitosandiclofenac_coatings_on_medical_grade_stainless_steel_for_hip_replacement_applicatio.pdf (2,73 MB)
MD5: 2333A1976E1086E909A8221F20E4011D
 
URL http://www.nature.com/articles/srep26653
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys.
Keywords:corrosion, corrosion resistance, chitosan, biocompatibility, biomaterials, biomedical materials, coatings, stainless steel
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:str. 1-17
Numbering:Letn. 6
PID:20.500.12556/DKUM-66406 New window
ISSN:2045-2322
UDC:57.089:669.14.018.8
ISSN on article:2045-2322
COBISS.SI-ID:19591446 New window
DOI:10.1038/srep26653 New window
NUK URN:URN:SI:UM:DK:GRAMBIYY
Publication date in DKUM:23.06.2017
Views:2073
Downloads:391
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
FINŠGAR, Matjaž, PERVA, Amra, STERGAR, Janja, GRADIŠNIK, Lidija and MAVER, Uroš, 2016, Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications. Scientific reports [online]. 2016. Vol. 6, p. 1–17. [Accessed 22 January 2025]. DOI 10.1038/srep26653. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=66406
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Record is a part of a journal

Title:Scientific reports
Shortened title:Sci. rep.
Publisher:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:Z1-6737
Name:Razvoj zelenih mešanic korozijskih inhibitorjev za kislinske postopke vrtin v industriji pridobivanja energentov

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:23.06.2017

Secondary language

Language:Slovenian
Keywords:korozija, hitozan, korozijska odpornost, biokompatibilnost, biomedicinski materiali, premazi, nerjaveče jeklo


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