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Title:Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications
Authors:Finšgar, Matjaž (Author)
Perva-Uzunalić, Amra (Author)
Stergar, Janja (Author)
Gradišnik, Lidija (Author)
Maver, Uroš (Author)
Files:.pdf Scientific_Reports_2016_Finsgar_et_al._Novel_chitosandiclofenac_coatings_on_medical_grade_stainless_steel_for_hip_replacement_applicatio.pdf (2,73 MB)
URL http://www.nature.com/articles/srep26653
Work type:Scientific work (r2)
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys.
Keywords:corrosion, corrosion resistance, chitosan, biocompatibility, biomaterials, biomedical materials, coatings, stainless steel
Year of publishing:2016
Number of pages:str. 1-17
Numbering:Letn. 6
ISSN on article:2045-2322
COBISS_ID:19591446 Link is opened in a new window
DOI:10.1038/srep26653 Link is opened in a new window
License:CC BY 4.0
This work is available under this license: Creative Commons Attribution 4.0 International
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Record is a part of a journal

Title:Scientific Reports
Publisher:Nature Publishing Group
COBISS.SI-ID:18727432 New window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:Z1-6737
Name:Razvoj zelenih mešanic korozijskih inhibitorjev za kislinske postopke vrtin v industriji pridobivanja energentov

Secondary language

Keywords:korozija, hitozan, korozijska odpornost, biokompatibilnost, biomedicinski materiali, premazi, nerjaveče jeklo


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