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Title:Effect of Bifidobacterium breve on the intestinal microbiota of coeliac children on gluten free diet : a pilot study
Authors:ID Quagliariello, Andrea (Author)
ID Aloisio, Irene (Author)
ID Bozzi Cionci, Nicole (Author)
ID Luiselli, Donata (Author)
ID D'Auria, Giuseppe (Author)
ID Martinez-Priego, Llúcia (Author)
ID Pérez-Villarroya, David (Author)
ID Langerholc, Tomaž (Author)
ID Pintarič, Maša (Author)
ID Mičetić-Turk, Dušanka (Author)
ID Di Gioia, Diana (Author)
Files:.pdf Nutrients_2016_Quagliariello_et_al._Effect_of_Bifidobacterium_breve_on_the_Intestinal_Microbiota_of_Coeliac_Children_on_a_Gluten_Free_Di.pdf (5,19 MB)
MD5: 0F525EBD0B3F155D50F2F79C97A055AA
 
URL http://www.mdpi.com/2072-6643/8/10/660
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FKBV - Faculty of Agriculture and Life Sciences
Abstract:Coeliac disease (CD) is associated with alterations of the intestinal microbiota. Although several Bifidobacterium strains showed anti-inflammatory activity and prevention of toxic gliadin peptides generation in vitro, few data are available on their efficacy when administered to CD subjects. This study evaluated the effect of administration for three months of a food supplement based on two Bifidobacterium breve strains (B632 and BR03) to restore the gut microbial balance in coeliac children on a gluten free diet (GFD). Microbial DNA was extracted from faeces of 40 coeliac children before and after probiotic or placebo administration and 16 healthy children (Control group). Sequencing of the amplified V3-V4 hypervariable region of 16S rRNA gene as well as qPCR of Bidobacterium spp., Lactobacillus spp., Bacteroides fragilis group Clostridium sensu stricto and enterobacteria were performed. The comparison between CD subjects and Control group revealed an alteration in the intestinal microbial composition of coeliacs mainly characterized by a reduction of the Firmicutes/Bacteroidetes ratio, of Actinobacteria and Euryarchaeota. Regarding the effects of the probiotic, an increase of Actinobacteria was found as well as a re-establishment of the physiological Firmicutes/Bacteroidetes ratio. Therefore, a three-month administration of B. breve strains helps in restoring the healthy percentage of main microbial components.
Keywords:coeliac disease, gluten free diet, probiotic, Bifidobacterium breve, intestinal microbiota, qPCR, next generation sequencing
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:str. 1-16
Numbering:Letn. 8, št. 10
PID:20.500.12556/DKUM-66358 New window
ISSN:2072-6643
UDC:579
ISSN on article:2072-6643
COBISS.SI-ID:4240940 New window
DOI:10.3390/nu8100660 New window
NUK URN:URN:SI:UM:DK:XBMSTWKM
Publication date in DKUM:22.06.2017
Views:2591
Downloads:274
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
QUAGLIARIELLO, Andrea, ALOISIO, Irene, BOZZI CIONCI, Nicole, LUISELLI, Donata, D’AURIA, Giuseppe, MARTINEZ-PRIEGO, Llúcia, PÉREZ-VILLARROYA, David, LANGERHOLC, Tomaž, PINTARIČ, Maša, MIČETIĆ-TURK, Dušanka and DI GIOIA, Diana, 2016, Effect of Bifidobacterium breve on the intestinal microbiota of coeliac children on gluten free diet : a pilot study. Nutrients [online]. 2016. Vol. 8, no. 10, p. 1–16. [Accessed 26 March 2025]. DOI 10.3390/nu8100660. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=66358
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Record is a part of a journal

Title:Nutrients
Shortened title:Nutrients
Publisher:MDPI
ISSN:2072-6643
COBISS.SI-ID:2948140 New window

Document is financed by a project

Funder:EC - European Commission
Funding programme:FP7
Project number:613912
Name:Traditional food network to improve the transfer of knowledge for innovation
Acronym:TRAFOON

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:22.06.2017

Secondary language

Language:Slovenian
Keywords:celiakija, brezglutenska dieta, probiotik, Bifidobacterium breve, črevesna mikrobiota, qPCR, verižna reakcija s polimerazo, sekvenciranje nove generacije, NGS


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