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Title:Transferin z zmanjšanim deležem ogljikovih hidratov (CDT) kot označevalec sindroma odvisnosti od alkohola
Authors:ID Kravos, Matej (Author)
ID Malešič, Ivan (Author)
Files:.pdf Zdravniski_vestnik_2008_Kravos,_Malesic_CARBOHYDRATE-DEFICIENT_TRANSFERRIN_(CDT)_AS_A_MARKER_OF_ALCOHOL_DEPENDENCY.PDF (155,95 KB)
MD5: 2EF0057804C6FA04A2CD66A1A97A049A
 
URL http://vestnik.szd.si/index.php/ZdravVest/article/view/464
 
Language:Slovenian
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Izhodišča: Čezmerno uživanje alkohola prične spreminjati strukturo transferina v transferin z zmanjšanim deležem ogljikohidratov (CDT). Od vseh znanih laboratorijskih označevalcev je edino CDT specifičen, noben pa ni dovolj občutljiv za dokazovanje odvisnosti od alkohola. Metode: V raziskavi smo hotelipotrditi odvisnost od alkohola s pomočjo vprašalnikov in laboratorijskihoznačevalcev, s posebnim poudarkom na CDT. Rezultati: Vključenih je bilo 68 (92,6% moških, 7,4% žensk) krvodajalcev in ambulantnih kontrolnih oseb ter 186 (89,2% moških, 10,8% žensk), bolnišnično zdravljenih zaradi odvisnosti od alkohola. Prvim smo označevalce določili enkrat, drugim ob sprejemu v bolnišnico, po 14 in po 42 dneh. Odvisni od alkohola so imeli statistično značilno zvišane vrednosti CDT, glutamat dehidrogenaze (GLDH), aspartat-aminotransferaze (AST), alanin-aminotransferaze (ALT), gama-glutamil transferaze (GGT), povprečnega volumna eritrocitov (MCV) in znižane vrednosti sečnine. Najbolj zanesljiv je bil CDT z visokima specifičnostjo (91,2%) in občutljivostjo (81,4%). Površina pod krivuljo ROC je bila izjemna z 99,9%. Statistično značilna je bila tudi kinetika normalizacije CDT, AST, ALT, GGT, MCV in kreatinina po 14 dneh ter CDT, AST, GGT, MCV in kreatinina po 42 dneh abstinence. Potek normalizacije vrednosti CDT smo ocenili kot klinično najuporabnejši. Diagnostično najpomembnejša je bila kombinacija CDT, MCV in AST. Pomen GGT je bil nižji od naših pričakovanj. Zaključki: V naši populaciji je CDT, v primerjavi z ostalimi, najbolj specifičen označevalec z visoko občutljivostjo. Kot samostojen označevalec ali kot presejalni test odvisnosti od alkohola pa ni dovolj zanesljiv. Njegova uporabnost je ključna v diagnostiki, kontroli abstinence in izvedenstvu, vendar le v kombinaciji z ostalimi laboratorijskimi označevalci.
Keywords:biološki označevalec, etanol, diagnostika odvisnosti, konstelacija preiskav, abstinenca
Publication status:Published
Publication version:Version of Record
Year of publishing:2008
Number of pages:str. 189-198
Numbering:Letn. 77, št. 3
PID:20.500.12556/DKUM-65260 New window
ISSN:1318-0347
UDC:613.8
ISSN on article:1318-0347
COBISS.SI-ID:24200153 New window
NUK URN:URN:SI:UM:DK:MTZTJM9A
Publication date in DKUM:27.03.2017
Views:23854
Downloads:316
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
KRAVOS, Matej and MALEŠIČ, Ivan, 2008, Transferin z zmanjšanim deležem ogljikovih hidratov (CDT) kot označevalec sindroma odvisnosti od alkohola. Zdravniški vestnik. glasilo Slovenskega zdravniškega društva [online]. 2008. Vol. 77, no. 3, p. 189–198. [Accessed 23 January 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=65260
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Record is a part of a journal

Title:Zdravniški vestnik. glasilo Slovenskega zdravniškega društva
Publisher:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:27.03.2017

Secondary language

Language:English
Title:Carbohydrate-deficient transferin (CDT) as a marker of alcohol dependency
Abstract:Background: Excessive alcohol consumption starts to change the structure of transferrin into the carbohydrate-deficient transferrin (CDT). CDT is the onlyspecific laboratory marker for alcohol dependency. However no one at all is sensitive enough. Method: In our study we wanted to confirm the alcohol dependency by means of questionnaires and laboratory markers, particularly CDT. Results: Investigated were 68 (92.6% males, 7.4% females) general practicehealthy patients and blood donors and 186 (89.2% males, 10.8% females)inpatient alcoholics. A blood sample was taken once from every healthysubject and three times from every alcoholic: on admission to hospital, after 12 days and again after 42 days. In alcoholics we found statistically significantly elevated CDT, glutamate dehidrogenaze (GLDH), aspartate-aminotransferaze (AST), alanine-aminotransferaze (ALT), gamaglutamyltransferaze (GGT) and mean corpuscular volume (MCV) and decreased urea values. CDT was the most reliable marker with high specificity (91.2%) and sensitivity (81.4%). The area under ROC-curve was exceptional with 99.9%. The kinetics of CDT, AST, ALT, GGT, MCV and creatinine normalization after 14 days were also statistically significant as well as kinetics of CDT, AST, GGT,MCV and creatinine normalization after 42 days. We estimated the course of CDT value normalization as the most applicable. The most important diagnostic marker combination was composed by CDT, MCV and AST. GGT had lower importance as expected. Conclusions: In our population CDT was the most specific marker of all, attaining high sensitivity. But it was not reliable enough as the sole marker or as the screening one for alcohol dependency. Its main applicability is in diagnostics of alcoholism, control of alcohol abstention and forensic cases but solely in combination with other laboratory markers of alcoholism.
Keywords:biological marker, ethanol, diagnostics of dependency, constellation of medical investigations, abstinence


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