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Title:
Matematično modeliranje odziva sklopljenih celic beta na stimulacijo z glukozo
Authors:
ID
Bajt, Martina
(Author)
ID
Gosak, Marko
(Mentor)
More about this mentor...
ID
Stožer, Andraž
(Comentor)
Files:
UN_Bajt_Martina_2016.pdf
(2,62 MB)
MD5: 37179522971827A946B03E5F3F5BA474
Language:
Slovenian
Work type:
Undergraduate thesis
Typology:
2.11 - Undergraduate Thesis
Organization:
FNM - Faculty of Natural Sciences and Mathematics
Abstract:
V diplomskem delu preučujemo delovanje modela sklopljenih celic beta. Te endokrine celice se nahajajo v Langerhansovih otočkih in izločajo inzulin ter s tem uravnavajo raven glukoze v krvi. Samo delovanje teh celic je zelo kompleksno in sestoji iz številnih med seboj povezanih dinamičnih procesov. Zavoljo boljšega razumevanja se pri preučevanju pogosto poslužuje modeliranja in preučevanja modelov. V nalogi je podrobneje opisana fiziologija Langerhansovih otočkov in pregled razvoja modelov celic beta. V nadaljevanju predstavimo eksperimentalne tehnike, ki se uporabljajo za snemanje aktivnosti celic beta v akutnih rezinah trebušne slinavke miši, in večcelični model, s katerim smo izvajali simulacije. Rezultati pokažejo, da napoved modela dobro sovpada z eksperimentalnimi opažanji, v kolikor se upošteva heterogenost celic beta in časovni zamik, ki je posledica metabolnih procesov v celicah.
Keywords:
celice beta
,
medcelična sklopitev
,
Langerhansovi otočki
,
matematično modeliranje
,
simulacije
Place of publishing:
Maribor
Publisher:
[M. Bajt]
Year of publishing:
2016
PID:
20.500.12556/DKUM-64422
UDC:
519.673:616.379(043.2)
COBISS.SI-ID:
22801160
NUK URN:
URN:SI:UM:DK:SHGIBSPZ
Publication date in DKUM:
02.12.2016
Views:
2465
Downloads:
134
Metadata:
Categories:
FNM
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BAJT, Martina, 2016,
Matematično modeliranje odziva sklopljenih celic beta na stimulacijo z glukozo
[online]. Bachelor’s thesis. Maribor : M. Bajt. [Accessed 22 January 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=64422
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Secondary language
Language:
English
Title:
Mathematical modeling of the response of coupled beta cells to stimulation with glucose
Abstract:
In the thesis we study the functioning of a computational model of interconnected beta cells. These endocrine cells are located in islets of Langerhans and secrete insulin and thereby regulate the blood glucose level. The sole function of these cells is very complex and consists of many interconnected dynamic processes. Modeling and studying the models are often utilized for reasons of a better understanding on examining. In the thesis we describe the physiology of islet and provide an overview on the development and examination of beta cell models. Further we present experimental techniques used to record activity of beta cells in acute slices of the mouse pancreas, and a multicellular model on the basis of which we carried out simulations. The results show that the predictions of the model fit well with the experimental observations, if the heterogeneity of the beta cells and the time delay caused by the metabolic processes in cells are taken into the account
Keywords:
beta cells
,
intercellular coupling
,
islets of Langerhans islets
,
mathematical modeling
,
simulations
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