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Title:Simultaneous determination of phthalates, their metabolites, alkylphenols and bisphenol a using GC-MS in urine of men with fertility problems
Authors:ID Kranvogl, Roman (Author)
ID Knez, Jure (Author)
ID Miuc, Alen (Author)
ID Vončina, Ernest (Author)
ID Brodnjak-Vončina, Darinka (Author)
ID Vlaisavljević, Veljko (Author)
Files:.pdf Acta_Chimica_Slovenica_2014_Kranvogl_et_al._Simultaneous_determination_of_phthalates,_their_metabolites,_alkylphenols_and_bisphenol_A_us.pdf (103,03 KB)
MD5: 984157FBDFF9F93D5BE941D0A9C444D4
 
URL http://acta-arhiv.chem-soc.si/61/61-1-110.pdf
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:A GC-MS method was successfully applied to measure simultaneously the concentrations of endocrine disrupting compounds (5 dialkyl phthalates, 9 phthalate monoesters, 3 alkylphenols and bisphenol A) in 136 male urine samples. In the present study the method was validated and concentrations of EDCs were determined. The results were compared with results from other studies. Correlations between endocrine disrupting compounds and also correlations of endocrine disrupting compounds with two semen quality parameters are presented and evaluated. Significant positive correlations were found between almost all the endocrine disrupting compounds. The parameter sum of DEHP (SUM DEHP) was positively correlated to all the endocrine disrupting compounds but negatively to two semen quality parameters. Negative correlations between the endocrine disrupting compounds and the semen quality parameters could indicate that endocrine disrupting compounds could cause reproductive problems by decreasing the semen count and quality. This research will have helped to evaluate human exposure to endocrine disrupting compounds.
Keywords:endocrine disrupting compounds, fertility, fertility, phthalates, bisphenol A, alkylphenols, human urine
Publication status:Published
Publication version:Version of Record
Year of publishing:2014
Number of pages:str. 110-120
Numbering:Letn. 61, št. 1
PID:20.500.12556/DKUM-56121 New window
ISSN:1318-0207
UDC:543.21:663.2
ISSN on article:1318-0207
COBISS.SI-ID:17710102 New window
NUK URN:URN:SI:UM:DK:GTKMNUGH
Publication date in DKUM:21.12.2015
Views:1937
Downloads:175
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
KRANVOGL, Roman, KNEZ, Jure, MIUC, Alen, VONČINA, Ernest, BRODNJAK-VONČINA, Darinka and VLAISAVLJEVIĆ, Veljko, 2014, Simultaneous determination of phthalates, their metabolites, alkylphenols and bisphenol a using GC-MS in urine of men with fertility problems. Acta Chimica Slovenica [online]. 2014. Vol. 61, no. 1, p. 110–120. [Accessed 22 January 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=56121
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Record is a part of a journal

Title:Acta Chimica Slovenica
Shortened title:Acta Chim. Slov.
Publisher:Slovensko kemijsko društvo
ISSN:1318-0207
COBISS.SI-ID:14086149 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P2-0006
Name:Fizikalno kemijski pojavi na površinskih plasteh in uporaba nanodelcev

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:21.12.2015

Secondary language

Language:Slovenian
Abstract:S plinsko kromatografijo in masno spektrometrijo smo simultano določali koncentracije endokrinih motilcev (5 dialkil ftalatov, 9 monoalkil ftalatov, 3 alkilfenole in bisfenol A) v 136 vzorcih moških urinov. Rezultate smo primerjali z ostalimi študijami. Ovrednotili smo korelacije med endokrinimi motilci in korelacije med endokrinimi motilci ter parametri semena. Signifikantne pozitivne korelacije obstajajo med skoraj vsemi endokrinimi motilci. Parameter vsote DEHP (SUM DEHP) pozitivno korelira z vsemi endokrinimi motilci in negativno s paramateri kvalitete semena. Negativne korelacije med endokrinimi motilci ter parametri kvalitete semena nakazujejo, da lahko povzročajo probleme s plodnostjo z zmanjšanjem koncentracije in gibljivosti semena. Raziskava bo pripomogla k ovrednotenju izpostavljenosti ljudi vplivom endokrinih motilcev.
Keywords:analizna kemija, endokrini motilci, ftalati, urin, plinska kromatografija, kemijska analiza


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