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Title:Supercritical fluid chromatography and scale up study
Authors:ID Oman, Miha (Author)
ID Kotnik, Petra (Author)
ID Škerget, Mojca (Author)
ID Knez, Željko (Author)
Files:.pdf Acta_Chimica_Slovenica_2014_Oman_et_al._Supercritical_fluid_chromatography_and_scale_up_study.pdf (842,20 KB)
MD5: A00E3F779A16382BB0F81C3806676EFB
 
URL https://journals.matheo.si/index.php/ACSi/article/view/462
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:The influence of process parameters on supercritical fluid chromatography (SFC) and scale-up on to the preparative scale was investigated. In this scope, dependency of pressure, temperature, type and concentration of modifier, and type of stationary phase on the separation were examined separately. Experiments were performed on silica stationary phases in the range of pressures from 100 bar to 250 bar and temperatures from 30°C to 65°C, with use of ethanol and methanol as modifier. Results obtained on analytical scale were used for scale up on preparative (to production) scale. The aim of this study is presentation of the state-of-the-art of SFC through separate effects of process parameters on the separation and investigation of development, benefits and drawbacks of scaling-up process of the SFC.
Keywords:supercritical fluids, supercritical fluid chromatograpy, chromatography, scale up study, SFC
Publication status:Published
Publication version:Version of Record
Year of publishing:2014
Number of pages:str. 746-758
Numbering:Letn. 61, št. 4
PID:20.500.12556/DKUM-56060 New window
ISSN:1318-0207
UDC:543.544.3/.5:54-139
ISSN on article:1318-0207
COBISS.SI-ID:18308886 New window
NUK URN:URN:SI:UM:DK:0RMSOQQT
Publication date in DKUM:21.12.2015
Views:1897
Downloads:173
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
OMAN, Miha, KOTNIK, Petra, ŠKERGET, Mojca and KNEZ, Željko, 2014, Supercritical fluid chromatography and scale up study. Acta Chimica Slovenica [online]. 2014. Vol. 61, no. 4, p. 746–758. [Accessed 31 March 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=56060
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Record is a part of a journal

Title:Acta Chimica Slovenica
Shortened title:Acta Chim. Slov.
Publisher:Slovensko kemijsko društvo
ISSN:1318-0207
COBISS.SI-ID:14086149 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P2-0046
Name:Separacijski procesi in produktna tehnika

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:21.12.2015

Secondary language

Language:Slovenian
Abstract:Raziskali smo vpliv procesnih parametrov na kromatografijo s superkritičnimi fluidi (SFC) skupaj z povečevanjem obsega na preparativno merilo. V tem okviru smo posamezno raziskali odvisnost tlaka, temperature, tipa in koncentracije so-topila, ter tipa stacionarne faze na separacijo testnih komponent (kofeina in teofilina) s SFC. Eksperimente smo izvedli na napravah za SFC v analitičnem in pilotnem preparativnem merilu. Separacije smo izvajali na dveh stacionarnih fazah: čisti silica in silica 2-etilpiridina. Kot mobilno fazo smo uporabili CO2/metanol ali CO2/etanol pri povišanih tlakih in temperaturah. Rezultate eksperimentov iz SFC naprave v analitičnem merilu smo uporabili za povečevanje obsega na preparativno merilo. Cilj študije je bila evaluacija vpliva procesnih parametrov na separacijo testnih komponent in praktični prikaz povečevanja obsega in obratovanja pilotne preparativne naprave, ki sodi med večje podobne naprave v globalnem merilu.
Keywords:superkritični fluidi, kromatografija s superkritičnimi fluidi, superkritična kromatografija, separacijski procesi


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