Morphological and biochemical process changes in coronary arteries of diabetic patients

Bele, Uroš

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Title:	Morphological and biochemical process changes in coronary arteries of diabetic patients
Authors:	ID Bele, Uroš (Author)
Files:	http://www.webmedcentral.com/wmcpdf/Article_WMC002900.pdf
Language:	English
Work type:	Other
Typology:	1.25 - Other Component Parts
Organization:	MF - Faculty of Medicine
Abstract:	Diabetes mellitus is a group of metabolic disorders in which a person suffers from elevated blood sugar levels, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is being produced. Elevated levels of blood sugar in diabetic patients lead to a seriesof complications. These can be divided into acute and chronic, which arefurther categorized as non-vascular and vascular. The latter are a consequence of changes in the biochemical processes that occur in the vessel wall. These biochemical processes are based on four independent biochemical abnormalities: 1) increased polyol pathway flux, 2) increased formation of advanced glycation end products (AGEs), 3) activation of protein kinase C (PKC) and 4) increased hexosamine pathway flux. Independently or in combination, these processes lead to excessive production of free radicals from oxygen metabolism in mitochondria. The glucose-mediated increase of free-radical production and/or the reduction of antioxidant capacity cause changes in oxidative stress, thus changing tissue susceptibility to cell damage. Such a string of phenomena can lead to a closure of a coronary artery segment, which results in the infarction of the heart muscle in the area supplied by this coronary artery. Since cardiac infarction is the most common cause of death in diabetic patients, understanding and researching diabetic angiopathy is of great importance.
Year of publishing:	2012
PID:	20.500.12556/DKUM-31146
UDC:	616.379-008.64
ISSN on article:	2046-1690
COBISS.SI-ID:	512162104
NUK URN:	URN:SI:UM:DK:QZC7OTW5
Publication date in DKUM:	05.06.2012
Views:	1695
Downloads:	41
Metadata:
Categories:	Misc.
:	BELE, Uroš, 2012, Morphological and biochemical process changes in coronary arteries of diabetic patients. In : WebmedCentral.com [online]. [Accessed 23 March 2025]. Retrieved from: http://www.webmedcentral.com/wmcpdf/Article_WMC002900.pdf Copy citation