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Title:Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties
Authors:ID Tomić, Sergej (Author)
ID Rudolf, Rebeka (Author)
ID Brunčko, Mihael (Author)
ID Anžel, Ivan (Author)
ID Savić, V. (Author)
ID Čolić, Miodrag (Author)
Files:.pdf European_Cells_and_Materials_2012_Tomic_et_al._Response_of_monocyte-derived_dendritic_cells_to_rapidly_solidified_nickel-titanium_ribbon.pdf (1,35 MB)
MD5: 46D6B99513E650ADE5A0C66E33163A24
PID: 20.500.12556/dkum/8794315e-04c0-4719-a625-4e4aab07621e
 
URL http://www.ecmjournal.org/journal/papers/vol023/vol023a05.php
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Abstract:Ni-Ti Shape Memory Alloys (SMAs) have attracted considerable attention as biomaterials for medical devices. However, the biocompatibility of Ni-Ti SMAs is often unsatisfactory due to their poor surface structure. Here we prepared Rapidly Solidified (RS) Ni-Ti SMA ribbons by melt-spinning and their surface was characterised by Augerelectron spectroscopy, X-ray photoelectron spectrometry and scanning electron microscopy. The biocompatibility of the produced ribbons and their immunomodulatory properties were studied on human monocyte-derived dendritic cells (MoDCs). We showed that melt-spinning of Ni-Ti SMAs can form a thin homogenous oxide layer, which improves their corrosion resistance and subsequent toxicity to MoDCs. Ni-Ti RS ribbons stimulated the maturation of MoDCs, as detected by changes in the cells' morphology and increased expression of HLA-DR, CD86, CD40 and CD83 molecules. However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-β-producing CD4+T cells. On the other hand, in the presence of lipopolysaccharide, an important pro-inflammatory biomolecule, Ni-Ti RS ribbons enhanced the allostimulatory and Th1 polarising capacity of MoDCs, whereas the production of Th2 and Th17 cytokines was down-regulated. In conclusion, Ni-Ti RS ribbons possess substantial immunomodulatory properties on MoDCs. These findings might be clinically relevant, because implanted Ni-Ti SMA devices can induce both desired and adverse effects on the immune system, depending on the microenvironmental stimuli.
Keywords:nickel-titanium alloy, biocompatibility, cytokines, immunomodulation, monocyte-derived dendritic cells
Publication status:Published
Publication version:Version of Record
Year of publishing:2012
Number of pages:str. 58-80
Numbering:Letn. 23
PID:20.500.12556/DKUM-27240-d1276669-88df-d96d-7735-8604d2a7f30a New window
ISSN:1473-2262
UDC:669:61
ISSN on article:1473-2262
COBISS.SI-ID:15705366 New window
DOI:10.22203/eCM.v023a05 New window
NUK URN:URN:SI:UM:DK:PQFJBRAW
Publication date in DKUM:01.06.2012
Views:2084
Downloads:376
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
TOMIĆ, Sergej, RUDOLF, Rebeka, BRUNČKO, Mihael, ANŽEL, Ivan, SAVIĆ, V. and ČOLIĆ, Miodrag, 2012, Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties. European Cells & Materials [online]. 2012. Vol. 23, p. 58–80. [Accessed 22 January 2025]. DOI 10.22203/eCM.v023a05. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=27240
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Record is a part of a journal

Title:European Cells & Materials
Shortened title:Eur. Cells Mater.
Publisher:AO Research Institute Davos
ISSN:1473-2262
COBISS.SI-ID:4545306 New window

Secondary language

Language:Slovenian
Keywords:nikelj-titanova zlitina, biokompatibilnost, citokini, imunomodulacija, monocitne dendritične celice


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