Your browser does not allow JavaScript!
JavaScript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser.
|
|
SLO
|
ENG
|
Cookies and privacy
DKUM
EPF - Faculty of Business and Economics
FE - Faculty of Energy Technology
FERI - Faculty of Electrical Engineering and Computer Science
FF - Faculty of Arts
FGPA - Faculty of Civil Engineering, Transportation Engineering and Architecture
FKBV - Faculty of Agriculture and Life Sciences
FKKT - Faculty of Chemistry and Chemical Engineering
FL - Faculty of Logistic
FNM - Faculty of Natural Sciences and Mathematics
FOV - Faculty of Organizational Sciences in Kranj
FS - Faculty of Mechanical Engineering
FT - Faculty of Tourism
FVV - Faculty of Criminal Justice and Security
FZV - Faculty of Health Sciences
MF - Faculty of Medicine
PEF - Faculty of Education
PF - Faculty of Law
UKM - University of Maribor Library
UM - University of Maribor
UZUM - University of Maribor Press
COBISS
Faculty of Business and Economic, Maribor
Faculty of Agriculture and Life Sciences, Maribor
Faculty of Logistics, Celje, Krško
Faculty of Organizational Sciences, Kranj
Faculty of Criminal Justice and Security, Ljubljana
Faculty of Health Sciences
Library of Technical Faculties, Maribor
Faculty of Medicine, Maribor
Miklošič Library FPNM, Maribor
Faculty of Law, Maribor
University of Maribor Library
Bigger font
|
Smaller font
Introduction
Search
Browsing
Upload document
For students
For employees
Statistics
Login
First page
>
Show document
Show document
Title:
OPTIMIZACIJA PROCESNIH POGOJEV KRISTALIZACIJE FARMACEVTSKE UČINKOVINE
Authors:
ID
Ivić, Urška
(Author)
ID
Goršek, Andreja
(Mentor)
More about this mentor...
ID
Zupančič, Silvo
(Comentor)
Files:
VS_Ivic_Urska_2011.pdf
(2,41 MB)
MD5: 2FFD143164404F1C40DB98CC81EA755F
PID:
20.500.12556/dkum/8e15edf1-3716-47b4-831c-08418e3660ed
Language:
Slovenian
Work type:
Undergraduate thesis
Organization:
FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:
Kristalizacija je pomembna kemijska in tehnološka operacija, s katero iz produkta odstranimo nečistoče, zagotovimo pravilno polimorfno obliko ter želeno velikost in obliko delcev. Pri kristalizaciji je pomembna izbira primernega topila, saj je od tega odvisna uspešnost čiščenja. Diplomsko delo predstavlja določitev najprimernejšega topila za kristalizacijo in študijo vplivov procesnih parametrov na potek kristalizacije surovega produkta SIK-a (4'-[(2-Butil-4-okso-1,3-diazaspiro[4,4]non-1-en-3-il)metil]bifenil-2-karbonitril). SIK je ključni intermediat za sintezo zdravilne učinkovine Irbesartan, ta pa se v farmacevtski industriji uporablja kot učinkovina za zdravljenje bolezni srca in ožilja, centralnega živčevja, glavkoma, retinopatije ter diabetične nefropatije. Z določitvijo najprimernejšega topila za kristalizacijo in procesnih parametrov, smo na koncu izolirali produkt SIK, ki je ustrezal vsem zahtevam (oblika, čistota, izkoristek, IR, NMR, EA).
Keywords:
kristalizacija
,
procesni pogoji
,
topilo
,
cianoirbesartan (SIK)
Place of publishing:
Maribor
Publisher:
[U. Ivić]
Year of publishing:
2011
PID:
20.500.12556/DKUM-18962
UDC:
66.065:548(043.2)
COBISS.SI-ID:
15160598
NUK URN:
URN:SI:UM:DK:RTUEKKER
Publication date in DKUM:
23.06.2011
Views:
3184
Downloads:
335
Metadata:
Categories:
KTFMB - FKKT
Cite this work
Plain text
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
IVIĆ, Urška, 2011,
OPTIMIZACIJA PROCESNIH POGOJEV KRISTALIZACIJE FARMACEVTSKE UČINKOVINE
[online]. Bachelor’s thesis. Maribor : U. Ivić. [Accessed 2 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=18962
Copy citation
Average score:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 votes)
Your score:
Voting is allowed only for
logged in
users.
Share:
Similar works from our repository:
Sodobna oprema za zaščito in reševanje
Sistem varstva pred naravnimi in drugimi nesrečami v Občini Sevnica
Vključevanje izkušenj z vaj in nesreč v programe usposabljanja različnih reševalcev
Organiziranost sistema javnega alarmiranja in klic v sili 112
Vloga operativnega managementa pri razvoju prostovoljnega gasilstva
Similar works from other repositories:
Vpliv družbenih omrežij na pospeševanje prodaje kozmetičnih izdelkov
Vpliv družbenih omrežij na zdravljenje aknaste kože v Sloveniji
Mnenje slovenskih uporabnikov Instagrama o družbeni odgovornosti spletnih vplivnežev
Kriza slovenskega založništva
Izbiranje optimalne strategije za oglaševanje na družbenih omrežjih s pomočjo spletnih vplivnežev
Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.
Secondary language
Language:
English
Title:
OPTIMIZATION OF PROCESS PARAMETERS FOR CRYSTALIZATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
Abstract:
Crystallization is an important chemical and technological operation through which we eliminate impurity from the product, assure the correct polymorph shape and the length and shape of parts. During crystallization the choice of the appropriate solvent is very important because the efficiency of the cleaning depends on it. Thesis defines the most suitable solvent for crystallization and the study of the influences that the process parameters have on the course of crystallization of the final raw product SIK (4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]biphenyl-2-carbonitrile). SIK is a key pharmaceutical intermediate for the synthesis of the active substances of Irbesartan, which is in pharmaceutical industry used as a substance for treating heart and vascular diseases, central nervous system, glaucoma, retinopathy and diabetic nephropathy. With defining the most suitable solvent for crystallization and process parameters we at the end isolated product SIK that suited all of set specifications (shape, cleanliness, usage, IR, NMR, EA).
Keywords:
crystallization
,
process conditions
,
solvent
,
cyanoirbesartan (SIK)
Comments
Leave comment
You must
log in
to leave a comment.
Comments (0)
0 - 0 / 0
There are no comments!
Back
