| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font
First page > Show document

Show document Help

Title:RAZVOJ IN UPORABA MIKRO PLINSKE KROMATOGRAFIJE ZA DOLOČANJE ATMOSFERE V FARMACEVTSKI EMBALAŽI
Authors:ID Kocjančič, Tjaša (Author)
ID Kolar, Mitja (Mentor) More about this mentor... New window
ID Brodnjak - Vončina, Darinka (Comentor)
Files:.pdf VS_Kocjancic_Tjasa_2009.pdf (3,31 MB)
MD5: 406BA9F00250C52F5A127654A40A4195
PID: 20.500.12556/dkum/aab6a1ce-e905-4069-b37c-951eb9447a8c
 
Language:Slovenian
Work type:Undergraduate thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Namen diplomske naloge je bil s pomočjo mikro plinske kromatografije (µGC) razviti enostavno in zanesljivo analizno metodo za določevanje kisika in vode v farmacevtski embalaži ter jo ustrezno ovrednotiti. Najprej smo s pomočjo plinskih standardnih mešanic razvili metodo na µGC instrumentu ter optimizirali analizne pogoje (temperaturo vhoda, injektorja in kolone, čas črpanja vzorca, čas injiciranja in čas analize ter tlak kolone). Kot nosilni plin smo pri vseh analizah uporabili argon. Ker µGC instrument ni imel posebnega nastavka za injiciranje atmosfere iz farmacevtske embalaže, smo ga modificirali in opremili z injekcijsko iglo, ki smo jo dodatno zatesnili in z navojem privili na injektor. Za čim boljšo ponovljivost injiciranja pri določanju atmosfere v žepkih smo poskrbeli tako, da smo na žepke nanesli silikon (Tekasil-Neutral Profi), in ga sušili pri sobni temperaturi 72 ur. S pomočjo modificirane igle smo nato prodrli v notranjost žepka, ne da bi pri tem kontaminirali vsebino vzorca z zunanjo atmosfero. Metodo smo uspešno uporabili na več vzorcih ter jo primerjali s plinsko kromatografijo v povezavi z masno spektrometrijo.
Keywords:plinska kromatografija, mikro GC, toplotna prevodnost, TCD – detektor, farmacevtska embalaža.
Place of publishing:Maribor
Publisher:[T. Kocjančič]
Year of publishing:2009
PID:20.500.12556/DKUM-11950 New window
UDC:543.544.3:661.12(043.2)
COBISS.SI-ID:13926934 New window
NUK URN:URN:SI:UM:DK:5FL02OUM
Publication date in DKUM:22.12.2009
Views:3038
Downloads:423
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
:
KOCJANČIČ, Tjaša, 2009, RAZVOJ IN UPORABA MIKRO PLINSKE KROMATOGRAFIJE ZA DOLOČANJE ATMOSFERE V FARMACEVTSKI EMBALAŽI [online]. Bachelor’s thesis. Maribor : T. Kocjančič. [Accessed 3 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=11950
Copy citation
  
Average score:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Secondary language

Language:English
Title:DETERMINATION OF ATMOSPHERE IN PHARMACEUTICAL PACKAGES USING MICRO GAS CHROMATOGRAPHY
Abstract:The aim of the diploma thesis is to develop a simple and reliable analytical method for determination of oxygen and water content in pharmaceutical packaging blisters using micro gas chromatography (µGC). In the first place conditions of analytical procedure were optimised, namely inlet temperature, injector temperature, column temperature, sampling time, injection time, run time and column pressure. For this purpose standard gas mixtures were used. Argon was used as the carrier gas in the GC analysis. The µGC instrument was not equipped with an attachment for the injection of atmosphere from pharmaceutical packaging blisters. Consequently, the attachment had to be made especially from a modified hypodermic needle that further required sealing with a screw mount to the injector. For obtaining best reproducibility of injections for determination of atmosphere in pharmaceutical packages we applied silicon (Tekasil-Neutral Profi), which was then permitted to dry for 72 hours, so that it became completely dry. Using the modified hypodermic needle it was possible to penetrate into the interior of the blister. This made possible for the atmosphere in the blister to be sampled without possible contamination from the external atmosphere. The method was successfully applied to a number of samples and was compared with the existing method using gas chromatography coupled with mass spectrometry.
Keywords:gas chromatography, Micro GC, thermal conductivity, TCD – detector, Pharmaceutical Blister Packaging.


Comments

Leave comment

You must log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back
Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica