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Title:Ojačitev in glajenje kalcijevih celičnih signalov s primerjavo prenosa signalov v tehniki : doktorska disertacija
Authors:ID Grubelnik, Vladimir (Author)
ID Marhl, Marko (Mentor) More about this mentor... New window
Files:.pdf DR_Grubelnik_Vladimir_i2008.pdf (10,19 MB)
MD5: FBFFCA8FD0D56D761C6112AB2B6830C7
PID: 20.500.12556/dkum/695f43af-1bfe-410a-8cba-6d03b44c640e
 
Language:Slovenian
Work type:Dissertation
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:Tema doktorske disertacije sodi na področje celične signalizacije. Predstavljena je teoretična obravnava celične signalizacije, ki temelji na proteinskih kaskadah, katerih aktivacija je pogojena s koncentracijo prostih Ca2+ ionov v znotrajceličnem prostoru. Proučujemo vlogo proteinskih kaskad pri glajenju celičnih signalov s kratkim odzivnim časom in vlogo proteinskih kaskad pri ohranjanju pulzne oblike ojačanih signalov. Izdelana je analogija s prenosom signalov v elektrotehniki, pri čemer primerjamo delovanje bioloških sistemov z znanimi mehanizmi delovanja v električnih vezjih. V delu sta predstavljena dva ključna izvirna znanstvena prispevka. Pokažemo, da je glajenje pulznih signalov s hitrimi vklopno-izklopnimi karakteristikami zagotovljeno že z malim številom kaskadnih ciklov. Za ojačitev signalov, pri katerih je potrebno ohraniti njihovo obliko, pokažemo, da so večstopenjski kaskadni ojačevalci rešitev tako v bioloških kakor tudi v tehničnih sistemih.
Keywords:fizika, tehnika, celična signalizacija, kalcijeve oscilacije, proteinske kaskade, glajenje signalov, ojačitev signalov, elektronski sistemi, operacijski ojačevalnik, disertacije
Place of publishing:Maribor
Publisher:[V. Grubelnik]
Year of publishing:2008
PID:20.500.12556/DKUM-10661 New window
UDC:53:621.3:577.3(043.3)
COBISS.SI-ID:16655112 New window
NUK URN:URN:SI:UM:DK:YC2BIRRA
Publication date in DKUM:31.05.2009
Views:14814
Downloads:1133
Metadata:XML DC-XML DC-RDF
Categories:FNM
:
GRUBELNIK, Vladimir, 2008, Ojačitev in glajenje kalcijevih celičnih signalov s primerjavo prenosa signalov v tehniki : doktorska disertacija [online]. Doctoral dissertation. Maribor : V. Grubelnik. [Accessed 23 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=10661
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Secondary language

Language:English
Abstract:The doctoral thesis is in the field of cellular signalling. It is theoretically investigated the cellular signalling, which is based on protein cascades activated by an increased intracellular calcium concentration. In particular, it is analysed the role of protein cascades in smoothening of cellular signals with short reaction time and the role of protein cascades in amplification of signals which should preserve their form. An analogy with signal transduction in electrical engineering systems is conducted. The behaviour of biological systems is directly compared with known solutions in electrical engineering systems. In the thesis two main original scientific contributions are presented. First, it is shown that smoothening of oscillatory signals with fast on-off characteristics can be realised by a small number of cascade levels. Second, cascade amplifiers are also appropriate for amplifying signals which should preserve their form. This is a successful solution in biological as well as in electro engineering systems.


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