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Title:Enzyme cascade to enzyme complex phase-transition-like transformation studied by the maximum entropy production principle
Authors:ID Dobovišek, Andrej (Author)
ID Blaževič, Tina (Author)
ID Kralj, Samo (Author)
ID Fajmut, Aleš (Author)
Files:.pdf RAZ_Dobovisek_Andrej_2025.pdf (1,52 MB)
MD5: CD2D6DDEE8CD40E7E3FE54849D52C57A
 
URL https://doi.org/10.1016/j.xcrp.2024.102400
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:In biological cells, soluble enzymes often spontaneously reorganize into higher-order complexes called metabolons, providing regulatory advantages over individual soluble enzymes under specific conditions. Despite their importance, the mechanisms underlying metabolon formation remain unclear. Here we report a theoretical model that elucidates the spontaneous transition between soluble enzyme cascades and complexes, driven by fluctuations in intermediate metabolite concentrations. The model integrates the maximum entropy production principle (MEPP) and the Shannon information entropy (MaxEnt), Landau phase-transition theory, kinetic modeling, stability analysis, and metabolic control analysis. Our results show that soluble enzymes and enzyme complexes represent two distinct catalytic states with unique kinetic and regulatory properties. The transition from an enzyme cascade to an enzyme complex displays features of a first-order phasetransition, highlighting the system's tendency to reorganize into its most thermodynamically favorable state, providing a potential pathway for metabolic regulation.
Keywords:theoretical modeling, irreversible thermodynamics, maximum entropy production principle, Shannon information entropy, first-order phase transition, enzyme organization, enzyme cascade, enzyme complex
Publication status:In print
Submitted for review:16.11.2024
Article acceptance date:30.12.2024
Publication date:23.01.2025
Year of publishing:2025
Number of pages:str. 1-11
Numbering:Letn. 6, št. 2, št. članka 102400
PID:20.500.12556/DKUM-91789 New window
UDC:536.7
ISSN on article:2666-3864
COBISS.SI-ID:225246211 New window
DOI:10.1016/j.xcrp.2024.102400 New window
Publication date in DKUM:06.02.2025
Views:0
Downloads:1
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
DOBOVIŠEK, Andrej, BLAŽEVIČ, Tina, KRALJ, Samo and FAJMUT, Aleš, 2025, Enzyme cascade to enzyme complex phase-transition-like transformation studied by the maximum entropy production principle. Cell reports physical science [online]. 2025. Vol. 6, no. 2,  članka 102400, p. 1–11. [Accessed 17 April 2025]. DOI 10.1016/j.xcrp.2024.102400. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=91789
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Record is a part of a journal

Title:Cell reports physical science
Publisher:Cell Press, Elsevier
ISSN:2666-3864
COBISS.SI-ID:56382467 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0055-2022
Name:Biofizika polimerov, membran, gelov, koloidov in celic
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0099-2022
Name:Fizika mehkih snovi, površin in nanostruktur
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J2-4447-2022
Name:Vpliv mehanike in topologije membrane na celično ujetje bakterij, virionov in anorganskih delcev

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:23.01.2025

Secondary language

Language:Slovenian
Keywords:teoretično modeliranje, ireverzibilna termodinamika, princip največje proizvodnje entropije, Shannonova informacijska entropija, fazni prehod prvega reda, encimska organizacija, encimska kaskada, encimski kompleks


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