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Title:Discovery of novel biomarkers with extended non-coding RNA interactor networks from genetic and protein biomarkers
Authors:ID Jezernik, Gregor (Author)
ID Glavač, Damjan (Author)
ID Skok, Pavel (Author)
ID Krušič, Martina (Author)
ID Potočnik, Uroš (Author)
ID Gorenjak, Mario (Author)
Files:.pdf RAZ_Jezernik_Gregor_2024.pdf (9,14 MB)
MD5: D4D88D708FFA7CC31B7F1CF0701AACFE
 
URL https://doi.org/10.3390/ijms251810210
 
URL https://www.mdpi.com/1422-0067/25/18/10210
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Curated online interaction databases and gene ontology tools have streamlined the analysis of highly complex gene/protein networks. However, understanding of disease pathogenesis has gradually shifted from a protein-based core to complex interactive networks where non-coding RNA (ncRNA) is thought to play an essential role. As current gene ontology is based predominantly on protein-level information, there is a growing need to analyze networks with ncRNA. In this study, we propose a gene ontology workflow integrating ncRNA using the NPInter V5.0 database. To validate the proposed workflow, we analyzed our previously published curated biomarker datasets for hidden disease susceptibility processes and pharmacogenomics. Our results show a novel involvement of melanogenesis in psoriasis response to biological drugs in general. Hyperpigmentation has been previously observed in psoriasis following treatment with currently indicated biological drugs, thus calling attention to melanogenesis research as a response biomarker in psoriasis. Moreover, our proposed workflow highlights the need to critically evaluate computed ncRNA interactions within databases and a demand for gene ontology analysis of large miRNA blocks.
Keywords:gene ontology, non-coding RNA, disease pathogenesis
Publication status:Published
Publication version:Version of Record
Article acceptance date:18.09.2024
Publication date:23.09.2024
Publisher:MDPI
Year of publishing:2024
Number of pages:Str. 1-16
Numbering:Letn. 25, Št. 18
PID:20.500.12556/DKUM-91274 New window
UDC:575
ISSN on article:1422-0067
COBISS.SI-ID:208743939 New window
DOI:10.3390/ijms251810210 New window
Publication date in DKUM:06.12.2024
Views:0
Downloads:7
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
JEZERNIK, Gregor, GLAVAČ, Damjan, SKOK, Pavel, KRUŠIČ, Martina, POTOČNIK, Uroš and GORENJAK, Mario, 2024, Discovery of novel biomarkers with extended non-coding RNA interactor networks from genetic and protein biomarkers. International journal of molecular sciences [online]. 2024. Vol. 25, no. Št. 18, p. 1–16. [Accessed 13 April 2025]. DOI 10.3390/ijms251810210. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=91274
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
Publisher:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P3-0427-2022
Name:Sistemski pristopi k raziskavam človeškega genoma za personalizirano medicino kroničnih imunskih bolezni
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:I0-0029-2022
Name:Infrastrukturna dejavnost Univerze v Mariboru
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J3-9258-2018
Name:Molekularno genetski biooznačevalci in mehanizmi neodzivnosti na biološko zdravljenje zanti-TNF bolnikov s kroničnimi imunskimi boleznimi
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J3-4497-2022
Name:Neinvazivni multi-omski biooznačevalci v podtipih imunskih celic za personalizirano zdravljenje otroške astme in molekularni mehanizmi neodzivnosti na inhalacijske kortikosteroide

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License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

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