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Title:Design of in vitro hair follicles for different applications in the treatment of alopecia : a review
Authors:ID Žnidarič, Matej (Author)
ID Žurga, Žan Michel (Author)
ID Maver, Uroš (Author)
Files:.pdf Znidaric-2021-Design_of_In_Vitro_Hair_Follicle.pdf (2,39 MB)
MD5: 9449BA9DB5058D8ED35EFD19EB1608B5
 
URL https://doi.org/10.3390/biomedicines9040435
 
Language:English
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:The hair research field has seen great improvement in recent decades, with in vitro hair follicle (HF) models being extensively developed. However, due to the cellular complexity and number of various molecular interactions that must be coordinated, a fully functional in vitro model of HFs remains elusive. The most common bioengineering approach to grow HFs in vitro is to manipulate their features on cellular and molecular levels, with dermal papilla cells being the main focus. In this study, we focus on providing a better understanding of HFs in general and how they behave in vitro. The first part of the review presents skin morphology with an emphasis on HFs and hair loss. The remainder of the paper evaluates cells, materials, and methods of in vitro growth of HFs. Lastly, in vitro models and assays for evaluating the effects of active compounds on alopecia and hair growth are presented, with the final emphasis on applications of in vitro HFs in hair transplantation. Since the growth of in vitro HFs is a complicated procedure, there is still a great number of unanswered questions aimed at understanding the long-term cycling of HFs without losing inductivity. Incorporating other regions of HFs that lead to the successful formation of different hair classes remains a difficult challenge.
Keywords:hair follicle, alopecia, dermal papilla cells, hair transplantation, in vitro hair follicle models
Publication status:Published
Publication version:Version of Record
Submitted for review:22.03.2021
Article acceptance date:13.04.2021
Publication date:16.04.2021
Publisher:MDPI
Year of publishing:2021
Number of pages:Str. 1-19
Numbering:Letn. 9, št. 4, št. članka 435
PID:20.500.12556/DKUM-91133 New window
UDC:616.594.1
ISSN on article:2227-9059
COBISS.SI-ID:60163331 New window
DOI:10.3390/biomedicines9040435 New window
Publication date in DKUM:11.03.2025
Views:0
Downloads:2
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
ŽNIDARIČ, Matej, ŽURGA, Žan Michel and MAVER, Uroš, 2021, Design of in vitro hair follicles for different applications in the treatment of alopecia : a review. Biomedicines [online]. 2021. Vol. 9, no. 4,  članka 435, p. 1–19. [Accessed 14 April 2025]. DOI 10.3390/biomedicines9040435. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=91133
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Record is a part of a journal

Title:Biomedicines
Shortened title:Biomedicines
Publisher:MDPI AG
ISSN:2227-9059
COBISS.SI-ID:523006745 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P3-0036
Name:Bio-psiho-socialni model kvalitete življenja
Funder:ARRS - Slovenian Research Agency
Project number:J3-1762
Name:Nov inovativen pristop k zdravljenju pleničnega izpuščaja z uporabo plenic z vgrajenimi probiotičnimi bakterijami

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:16.04.2021

Secondary language

Language:Slovenian
Keywords:lasni folikli, alopecija, celice dermalne papile, presaditev las, modeli lasnih foliklov in vitro


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