| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font
First page > Show document

Show document Help

Title:Investigating the viability of epithelial cells on polymer based thin-films
Authors:ID Vihar, Boštjan (Author)
ID Rožanc, Jan (Author)
ID Krajnc, Boštjan (Author)
ID Gradišnik, Lidija (Author)
ID Milojević, Marko (Author)
ID Činč Ćurić, Laura (Author)
ID Maver, Uroš (Author)
Files:.pdf Vihar-2021-Investigating_the_Viability_of_Epit.pdf (20,37 MB)
MD5: 359220EFA8919F883BCA5FEA402A6F81
 
URL https://doi.org/10.3390/polym13142311
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:The development of novel polymer-based materials opens up possibilities for several novel applications, such as advanced wound dressings, bioinks for 3D biofabrication, drug delivery systems, etc. The aim of this study was to evaluate the viability of vascular and intestinal epithelial cells on different polymers as a selection procedure for more advanced cell-polymer applications. In addition, possible correlations between increased cell viability and material properties were investigated. Twelve polymers were selected, and thin films were prepared by dissolution and spin coating on silicon wafers. The prepared thin films were structurally characterized by Fourier transform infrared spectroscopy, atomic force microscopy, and goniometry. Their biocompatibility was determined using two epithelial cell lines (human umbilical vein endothelial cells and human intestinal epithelial cells), assessing the metabolic activity, cell density, and morphology. The tested cell lines showed different preferences regarding the culture substrate. No clear correlation was found between viability and individual substrate characteristics, suggesting that complex synergistic effects may play an important role in substrate design. These results show that a systematic approach is required to compare the biocompatibility of simple cell culture substrates as well as more complex applications (e.g., bioinks).
Keywords:HUIEC, HUVEC, morphology, polymers, thin films, viability
Publication status:Published
Publication version:Version of Record
Submitted for review:30.06.2021
Article acceptance date:09.07.2021
Publication date:14.07.2021
Publisher:MDPI
Year of publishing:2021
Number of pages:Str. 1-17
Numbering:Letn. 13, št. 14, št. članka 2311
PID:20.500.12556/DKUM-91076 New window
UDC:678
ISSN on article:2073-4360
COBISS.SI-ID:73616387 New window
DOI:10.3390/polym13142311 New window
Publication date in DKUM:18.10.2024
Views:0
Downloads:1
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
VIHAR, Boštjan, ROŽANC, Jan, KRAJNC, Boštjan, GRADIŠNIK, Lidija, MILOJEVIĆ, Marko, ČINČ ĆURIĆ, Laura and MAVER, Uroš, 2021, Investigating the viability of epithelial cells on polymer based thin-films. Polymers [online]. 2021. Vol. 13, no. 14,  članka 2311, p. 1–17. [Accessed 14 April 2025]. DOI 10.3390/polym13142311. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=91076
Copy citation
  
Average score:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Polymers
Shortened title:Polymers
Publisher:MDPI
ISSN:2073-4360
COBISS.SI-ID:517951257 New window

Document is financed by a project

Funder:Other - Other funder or multiple funders
Project number:5442-1/2018/59
Funder:Other - Other funder or multiple funders
Project number:5442-1/2018/60
Funder:ARRS - Slovenian Research Agency
Project number:P-0036
Funder:ARRS - Slovenian Research Agency
Project number:I0-0029
Name:Infrastrukturna dejavnost Univerze v Mariboru
Funder:ARRS - Slovenian Research Agency
Project number:J3-1762
Name:Nov inovativen pristop k zdravljenju pleničnega izpuščaja z uporabo plenic z vgrajenimi probiotičnimi bakterijami
Funder:ARRS - Slovenian Research Agency
Project number:J1-2470
Name:Biofunkcionalizacija 3D-tiskanih kovinskih zlitin kot novo nastajajoča strategija za zmanjšanje neželenih učinkov ortopedskih vsadkov
Funder:ARRS - Slovenian Research Agency
Project number:J1-9169
Name:Večfunkcionalne bioaktivne prevleke na različnih substratih za biomedicinske aplikacije
Funder:Other - Other funder or multiple funders
Funding programme:Young Researcher Programme

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:14.07.2021

Secondary language

Language:Slovenian
Keywords:morfologija, polimeri, tanke plasti, vitalnost


Comments

Leave comment

You must log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back
Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica