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Title:Novel magnetic iron oxide-dextran sulphate nanocomposites as potential anticoagulants: Investigating interactions with blood components and assessing cytotoxicity
Authors:ID Plohl, Olivija (Author)
ID Fras Zemljič, Lidija (Author)
ID Vihar, Boštjan (Author)
ID Vesel, Alenka (Author)
ID Gyergyek, Sašo (Author)
ID Maver, Uroš (Author)
ID Ban, Irena (Author)
ID Bračič, Matej (Author)
Files:.pdf 1-s2.0-S0144861724006957-main-on-line-published.pdf (892,02 KB)
MD5: 12A2452F263CFF4D1A4C6F239150AEEF
 
URL https://www.sciencedirect.com/science/article/pii/S0144861724006957?via%3Dihub
 
Language:English
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Abstract:Examining the critical role of anticoagulants in medical practice, particularly their central function in preventing abnormal blood clotting, is of the utmost importance. However, the study of interactions between blood proteins and alternative anticoagulant nano-surfaces is still understood poorly. In this study, novel approach involving direct functionalisation of magnetic iron oxide nanoparticles (MNPs) as carriers with sulphated dextran (s-dext) is presented, with the aim of evaluating the potential of magnetically-responsive MNPs@s-dext as anticoagulants. The physicochemical characterisation of the synthesised MNPs@s-dext includes crystal structure analysis, morphology study, surface and electrokinetic properties, thermogravimetric analysis and magnetic properties` evaluation, which confirms the successful preparation of the nanocomposite with sulfonate groups. The anticoagulant potential of MNPs@s-dext was investigated using a standardised activated partial thromboplastin time (APTT) test and a modified APTT test with a quartz crystal microbalance with dissipation (QCM-D) which confirmed the anticoagulant effect. Time-resolved solid-liquid interactions between the MNPs@s-dext and model blood proteins bovine serum albumin and fibrinogen were also investigated, to gain insight into their hemocompatibility, and revealed protein-repellence of MNPs@s-dext against blood proteins. The study also addressed comprehensive cytotoxicity studies of prepared nanocomposites, and provided valuable insights into potential applicability of MNPs@s-dext as a promising magnetic anticoagulant in biomedical contexts.
Keywords:dextran sulphate, magnetic nanoparticles, blood protein interactions, clot formation, anticoagulants, cytotoxicity studies
Publication status:Published
Publication version:Version of Record
Submitted for review:30.05.2024
Article acceptance date:06.07.2024
Publication date:14.07.2024
Publisher:Elsevier
Year of publishing:2024
Number of pages:13 str.
Numbering:Vol. 343, [article no.] 122469
PID:20.500.12556/DKUM-89595 New window
UDC:677.46:620.3
ISSN on article:1879-1344
COBISS.SI-ID:202837507 New window
DOI:10.1016/j.carbpol.2024.122469 New window
Publication date in DKUM:25.07.2024
Views:107
Downloads:28
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
PLOHL, Olivija, FRAS ZEMLJIČ, Lidija, VIHAR, Boštjan, VESEL, Alenka, GYERGYEK, Sašo, MAVER, Uroš, BAN, Irena and BRAČIČ, Matej, 2024, Novel magnetic iron oxide-dextran sulphate nanocomposites as potential anticoagulants: Investigating interactions with blood components and assessing cytotoxicity. Carbohydrate polymers [online]. 2024. Vol. 343,  122469. [Accessed 15 April 2025]. DOI 10.1016/j.carbpol.2024.122469. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=89595
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Record is a part of a journal

Title:Carbohydrate polymers
Shortened title:Carbohydr. polym.
Publisher:Elsevier Ltd.
ISSN:1879-1344
COBISS.SI-ID:130008067 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P2-0118-2022
Name:Tekstilna kemija in napredni tekstilni materiali
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P2-0082-2022
Name:Tankoplastne strukture in plazemsko inženirstvo površin
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J1-4416-2022
Name:Razvoj visokoobčutljive elektrokemijske metode na osnovi magnetnih polimernih nanokompozitov za določanje spojin antibiotikov v sledovih v okolijskih sistemih

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:Slovenian
Keywords:dekstran sulfat, magnetni nanodelci, interakcije krvnih beljakovin, nastajanje strdkov, antikoagulanti, študije citotoksičnosti


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