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Title:The role of methylation of host and/or human papillomavirus (HPV) DNA in management of cervical intraepithelial neoplasia grade 2 (CIN2) lesions
Authors:ID Dovnik, Andraž (Author)
ID Poljak, Mario (Author)
Files:.pdf Dovnik-2023-The_Role_of_Methylation_of_Host_an.pdf (340,44 KB)
MD5: D777FB9E07172E6F5C5BF12E8A615B75
 
URL https://doi.org/10.3390/ijms24076479
 
Language:English
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:Cervical intraepithelial neoplasia grade 2 (CIN2) is an intermediate stage between CIN 1, which is a low-grade lesion, and CIN3, which is the immediate precursor of cervical cancer (CC). Traditionally, CIN2 was regarded as a high-grade lesion and was treated with conization or ablative methods. In recent years, there has been a shift in the management of younger patients, who are now more often being managed conservatively due to frequent spontaneous CIN2 regression and possible adverse effects of treatment on future pregnancies. Because the risk of progression to CC still exists with conservative management, a personalized approach is needed to identify patients with a higher probability of progression. In this regard, research has focused on the role of host and human papillomavirus (HPV) gene methylation. This systematic review summarizes the current knowledge regarding conservative CIN2 management focusing on the main methylation markers and its implementation in conservative CIN2 management, and it describes major ongoing longitudinal studies on the subject. The review showed that DNA methylation is an accurate predictor of disease progression and a valid triage tool for HPV-positive women, with CIN2 performing better than triage cytology. Because virtually all CCs are methylation-positive, methylation-negative women at baseline have an extremely low risk of CC.
Keywords:cervical intraepithelial lesion, human papillomavirus, gene methylation
Publication status:Published
Publication version:Version of Record
Submitted for review:07.03.2023
Article acceptance date:28.03.2023
Publication date:30.03.2023
Publisher:MDPI
Year of publishing:2023
Number of pages:Str. 1-15
Numbering:Letn. 24, Št. 7, št. članka 6479
PID:20.500.12556/DKUM-89543 New window
UDC:618.1
ISSN on article:1422-0067
COBISS.SI-ID:147516675 New window
DOI:10.3390/ ijms24076479 New window
Publication date in DKUM:19.07.2024
Views:169
Downloads:10
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
DOVNIK, Andraž and POLJAK, Mario, 2023, The role of methylation of host and/or human papillomavirus (HPV) DNA in management of cervical intraepithelial neoplasia grade 2 (CIN2) lesions. International journal of molecular sciences [online]. 2023. Vol. 24, no. Št. 7,  članka 6479, p. 1–15. [Accessed 5 April 2025]. DOI 10.3390/ ijms24076479. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=89543
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
Publisher:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 New window

Document is financed by a project

Funder:EC - European Commission
Funding programme:H2020
Project number:847845
Name:RISK-BASED SCREENING FOR CERVICAL CANCER
Acronym:RISCC
Funder:ARRS - Slovenian Research Agency
Project number:P3-0083
Name:Odnosi parazitskega obstajanja

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:30.03.2023

Secondary language

Language:Slovenian
Keywords:intraepitelijska lezija materničnega vratu, človeški papiloma virus, metilacija genov


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