| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font
First page > Show document

Show document Help

Title:Optimiranje postopkov formulacije farmacevtskih učinkovin v porozne polimerne nosilce : magistrsko delo
Authors:ID Cesar, Teja (Author)
ID Knez Marevci, Maša (Mentor) More about this mentor... New window
ID Kravanja, Katja Andrina (Comentor)
ID Perva, Amra (Comentor)
Files:.pdf MAG_Cesar_Teja_2024.pdf (2,20 MB)
MD5: FFACA5C41A18C834F25F36040C35D411
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Namen magistrske naloge je bil optimizirati formulacijo polimernih nosilcev kot sistemov za dostavo farmacevtskih učinkovin. Cilj je bil izboljšati topnost izbranih farmacevtskih učinkovin ter doseči podaljšano sproščanje v simuliranih telesnih tekočinah. Polimerni nosilci so obetavni na področju razvoja sistemov s formuliranimi zdravili, saj lahko z ustrezno prilagoditvijo njihovih fizikalno-kemijskih lastnosti dosežemo izboljšano formuliranje in sproščanje farmacevtskih učinkovin. V sklopu laboratorijskega dela smo sintetizirali plastovite polimerne nosilce, v katere smo uspešno formulirali dve različni farmacevtski učinkovini z različno polarnostjo. Izbrana polimera sta bila hitozan in alginat. S procesom superkritičnega penjenja smo izdelali tudi porozne polimerne nosilce, kjer smo kot začetni polimer uporabili polikaprolakton. Kot farmacevtski učinkovini smo izbrali ketoprofen in klindamicin hidroklorid. Izbrali smo ju glede na njuno topnost v telesnih tekočinah. Ketoprofen se uporablja za zdravljenje akutne bolečine in je slabo topen, medtem ko je klindamicin hidroklorid bolj topen v telesnih tekočinah in se uporablja kot antibiotik. Karakterizacijo formuliranih polimernih nosilcev z vsebnostjo farmacevtskih učinkovin smo izvedli z vrstično elektronsko mikroskopijo in tehniko oslabljenega totalnega odboja infrardeče spektroskopije s Fourierjevo transformacijo. Z in vitro testiranjem sproščanja smo prikazali spreminjanje vsebnosti formuliranih farmacevtskih učinkovin v polimernih nosilcih glede na čas sproščanja, pridobljene vzorce smo analizirali s tekočinsko kromatografijo visoke ločljivosti in z UV-Vis spektrofotometrijo. Rezultati so nedvoumno pokazali, da je formulacija farmacevtskih učinkovin v polimerne nosilce omogočila podaljšano sproščanje v telesnih tekočinah. Ugotovitve kažejo, da so porozni polimerni nosilci bolj primerni za sisteme dostave zdravil s podaljšanim sproščanjem v primerjavi s plastovitimi polimernimi nosilci.
Keywords:farmacevtske učinkovine, polimerni nosilci, plastoviti polimeri, superkritično penjenje, in vitro sproščanje
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[T. Cesar]
Year of publishing:2024
Number of pages:1 spletni vir (1 datoteka PDF (X, 50 f.))
PID:20.500.12556/DKUM-87227 New window
UDC:615.015.1(043.2)
COBISS.SI-ID:195532291 New window
Publication date in DKUM:03.04.2024
Views:273
Downloads:63
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
:
CESAR, Teja, 2024, Optimiranje postopkov formulacije farmacevtskih učinkovin v porozne polimerne nosilce : magistrsko delo [online]. Master’s thesis. Maribor : T. Cesar. [Accessed 18 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=87227
Copy citation
  
Average score:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share


Searching for similar works...Please wait....
Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:10.03.2024

Secondary language

Language:English
Title:Optimisation of formulation processes for active pharmaceutical ingredients in porous polymeric carriers
Abstract:The aim of the master's thesis was to prepare the optimized polymer-based formulation for drug delivery. The objective was to improve the solubility of selected drugs and to achieve their sustained release in simulated body fluids. Polymer-based carriers are promising for the development of drug delivery systems, as improved drug release can be achieved by appropriate tailoring of their physiochemical properties. The experimental work involved the synthesis of layered polymeric carriers in which two drugs with different polarities were successfully formulated. The selected polymers for the preparation of layered carriers were chitosan and alginate. Porous polymeric carriers were also prepared by supercritical CO2-assisted foaming, using polycaprolactone as the starting polymer. Ketoprofen and clindamycin hydrochloride were selected based on their polarity and solubility in body fluids. Ketoprofen is anti-inflammatory drug used to treat acute pain and is poorly soluble in water-based media, while clindamycin hydrochloride is used as an antibiotic and is freely soluble in body fluids. The characterization of the formulated drug-loaded polymeric carriers was carried out using Scanning Electron Microscopy and Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy. In vitro drug release tests were used to evaluate the percentage of the drugs released from polymer carriers as a function of time. The concentrations of released drugs were determined using High-Performance Liquid Chromatography and UV-Vis spectrophotometry. The results showed that the formulation of drug-loaded polymeric carriers enabled prolonged drug release into simulated body fluids. In addition, it was shown that the porous polymeric carriers are better suited for sustained-release drug delivery systems compared to layered polymer carriers.
Keywords:drugs, polymer carriers, layered polymers, supercritical foaming, in vitro drug release


Comments

Leave comment

You must log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back
Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica