| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font
First page > Show document

Show document Help

Title:Analiza povezav med arterijsko togostjo, ekspresijskim profilom mikroRNK iz periferne krvi in stopnjo aterosklerotične prizadetosti koronarnih arterij pri bolnikih z normalnim ali zmanjšanim ledvičnim delovanjem
Authors:ID Piko, Nejc (Author)
ID Ekart, Robert (Mentor) More about this mentor... New window
ID Naji, Husam Franjo (Comentor)
Files:.pdf DOK_Piko_Nejc_2023.pdf (3,48 MB)
MD5: B73C4FBD3AFA03B05BEEC0E32139C6A3
 
Language:Slovenian
Work type:Doctoral dissertation
Typology:2.08 - Doctoral Dissertation
Organization:MF - Faculty of Medicine
Abstract:Ateroskleroza je kronična vnetna bolezen arterij, ki vodi v zoženje svetline žil ter v ishemično okvaro tkiv in organov v povirju prizadetih arterij. Med srčnožilne bolezni uvrščamo ishemično bolezen srca, periferno arterijsko bolezen, bolezni možganskih žil ter anevrizme prsne in trebušne aorte. Predstavljajo enega izmed najpogostejših vzrokov umrljivosti v razvitem svetu in so neposredna posledica napredovale ateroskleroze. Kronična ledvična bolezen je pomemben dejavnik tveganja za srčnožilne bolezni. Arterijska togost označuje zmanjšano podajnost arterij in je povezana s strukturnimi in funkcionalnimi spremembami v žilni steni in pretoku krvi. MikroRNK so ključni epigenetski regulatorji številnih procesov v telesu in imajo velik potencial pri prepoznavanju in zdravljenju srčnožilnih bolezni. V naši študiji smo analizirali povezave med koronarno arterijsko boleznijo, periferno arterijsko boleznijo in arterijsko togostjo pri bolnikih z in brez kronične ledvične bolezni. Prav tako smo analizirali ekspresijski profil mikroRNK molekul pri bolnikih z najvišjimi in najnižjimi vrednostmi hitrosti karotidno-femoralnega pulznega vala. Rezultati naše študije dokazujejo, da imajo bolniki s kronično ledvično boleznijo višjo arterijsko togost ter nižji gleženjski indeks. Pri bolnikih s kronično ledvično boleznijo je bilo nekoliko več trožilne koronarne arterijske bolezni, vendar razlika v primerjavi z bolniki brez kronične ledvične bolezni ni bila statistično pomembna. V ekspresiji mikroRNK razlik ni bilo.
Keywords:ateroskleroza, arterijska togost, kronična ledvična bolezen, srčnožilna bolezen, mikro RNK
Place of publishing:Maribor
Year of publishing:2022
PID:20.500.12556/DKUM-82314 New window
COBISS.SI-ID:141963779 New window
Publication date in DKUM:16.02.2023
Views:568
Downloads:94
Metadata:XML DC-XML DC-RDF
Categories:MF
:
PIKO, Nejc, 2022, Analiza povezav med arterijsko togostjo, ekspresijskim profilom mikroRNK iz periferne krvi in stopnjo aterosklerotične prizadetosti koronarnih arterij pri bolnikih z normalnim ali zmanjšanim ledvičnim delovanjem [online]. Doctoral dissertation. Maribor. [Accessed 12 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=82314
Copy citation
  
Average score:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:13.08.2022

Secondary language

Language:English
Title:The association between arterial stiffness parameters, microRNA expression profile from peripheral blood and the extent of coronary artery disease in patients with normal or reduced kidney function
Abstract:Atherosclerosis is a chronic inflammatory disease of the arteries that leads to narrowing of the lumen of blood vessels and ischemic damage to target tissues and organs. The spectrum of cardiovascular disease includes ischemic heart disease, peripheral artery disease, cerebrovascular disease, thoracic and abdominal aortic aneurysms. Cardiovascular disease is one of the most common causes of mortality in the devel-oped world and is a direct consequence of advanced atherosclerosis. Chronic kidney disease is an important risk factor for cardiovascular disease. Arterial stiffness indi-cates decreased arterial distensibility and is associated with structural and functional changes of vascular walls and blood flow. MicroRNAs are key epigenetic regulators of many processes in the body and have great potential in the recognition and treatment of cardiovascular disease. In our study, we analysed the associations between coronary artery disease, peripheral artery disease and arterial stiffness in patients with and without chronic kidney disease. Additionally, we performed an analysis of microRNA expression in patients with the highest and lowest carotid-femoral pulse wave velocities. We demonstrated that patients with chronic kidney disease have higher arterial stiffness and decreased ankle-brachial index. More patients with three vessel coronary artery disease had chronic kidney disease, although the difference was not statistically significant. There were no differences in microRNA expression profile between patients with 10 highest and 10 lowest values of carotid-femoral pulse wave velocity.
Keywords:atherosclerosis, arterial stiffness, chronic kidney disease, cardiovascular disease, micro RNA


Comments

Leave comment

You must log in to leave a comment.

Comments (0)
0 - 0 / 0
 
There are no comments!

Back
Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica