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Title:Antiproliferacijski in antioksidativni učinki nekaterih razvejanih in kratkoverižnih maščobnih kislin
Authors:ID Pertinač, Špela (Author)
ID Langerholc, Tomaž (Mentor) More about this mentor... New window
ID Tušar, Livija (Comentor)
Files:.pdf MAG_Pertinac_Spela_2018.pdf (3,63 MB)
MD5: 727E63AC41C811E44AE2F509ED80A3CE
PID: 20.500.12556/dkum/2beed6d8-0a19-4432-a6b2-0cffdd20e8a7
 
Language:Slovenian
Work type:Master's thesis/paper
Organization:FKBV - Faculty of Agriculture and Life Sciences
Abstract:Maščobne kisline (MK) so pomembne pri vzdrževanju ravnovesja črevesne mikroflore in metabolizma. Njihova ustrezna količina zmanjšuje pojavnost številnih bolezni (alergij, astme, raka ter avtoimunskih, presnovnih in nevroloških bolezni). Namen raziskave je bil ugotoviti, če izbrane kratkoverižne alifatske (KVMK) in razvejane maščobne kisline (RMK) vplivajo na proliferacijo človeških epitelnih celic linije H4 in Caco-2 in če povzročajo oksidativni stres v celicah TLT. MTT-test smo uporabili kot pokazatelj vpliva MK na proliferacijo celic, barvilo DCFH-DA pa kot pokazatelj oksidativnega stresa. Rezultati so pokazali, da visoke koncentracije MK vplivajo na zmanjšanje proliferacije pri celičnih linijah H4 in Caco-2. MK v celicah TLT povzročajo oksidativni stres že pri najnižjih testiranih koncentracijah. Pri mlečni, heksanojski, valerični, izovalerični in 2-metilbutirični kislini je pri najvišjih koncentracijah dodanih MK oksidativni stres najvišji, medtem ko propanojska, Na-butirat in 4-metilvalerična kislina pri najvišji koncentraciji celo zavirajo oksidativni stres.
Keywords:maščobne kisline, proliferacija celic, oksidativni stres
Place of publishing:Maribor
Year of publishing:2018
PID:20.500.12556/DKUM-72334 New window
NUK URN:URN:SI:UM:DK:2QVNKP04
Publication date in DKUM:27.09.2018
Views:1656
Downloads:169
Metadata:XML DC-XML DC-RDF
Categories:FKBV
:
PERTINAČ, Špela, 2018, Antiproliferacijski in antioksidativni učinki nekaterih razvejanih in kratkoverižnih maščobnih kislin [online]. Master’s thesis. Maribor. [Accessed 17 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=72334
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:19.09.2018

Secondary language

Language:English
Title:Antiproliferative and Antioxidant Effects of Selected Branched-chain and Short-chain Fatty Acids
Abstract:Fatty acids (FAs) are important in supporting the intestinal microflora and metabolism. Physiological amounts of FAs reduce the occurrences of many diseases (allergies, asthma, cancer and autoimmune, metabolic and neurological diseases). The aim of the study was to determine if selected short chain aliphatic fatty acids (SCFA) and branched chain fatty acids (BCFA) affect the proliferation of human epithelial cell lines H4 and Caco-2 and oxidative stress in macrophage cells TLT. An MTT test was used to monitor cell proliferation and DCFH-DA dye was used as an indicator of oxidative stress. The results showed that high FA concentrations cause the reduction of proliferation in cell lines H4 and Caco-2. FAs caused oxidative stress in TLT cells even in the lowest applied concentration range. Lactic, hexanoic, valeric, isovaleric and 2-methylbutyric acids caused oxidative stress at highest concentrations applied in the test, while propanoic, Na-butyrate and 4-methylvaleric acids even inhibited oxidative stress at the highest concentration.
Keywords:fatty acids, prioliferation, oxidative stress


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