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Title:Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens : from identification to application
Authors:ID Mraheil, Mobarak (Author)
ID Billion, André (Author)
ID Kuenne, Carsten (Author)
ID Pischimarov, Jordan (Author)
ID Kreikemayer, Bernd (Author)
ID Engelmann, Sussane (Author)
ID Hartke, Axel (Author)
ID Giard, Jean-Christophe (Author)
ID Rupnik, Maja (Author)
ID Vorwerk, Sonja (Author)
ID Beier, Markus (Author)
ID Retey, Julia (Author)
ID Hartsch, Thomas (Author)
ID Jacob, Anette (Author)
ID Cemič, Franz (Author)
ID Hemberger, Jürgen (Author)
ID Chakraborty, Trinad (Author)
ID Hain, Torsten (Author)
Files:.pdf Microbial_Biotechnology_2010_Mraheil_et_al._Comparative_genome-wide_analysis_of_small_RNAs_of_major_Gram-positive_pathogens_from_identif.pdf (698,61 KB)
MD5: 9373F551AB779D06F96B5F7E7B99B43C
PID: 20.500.12556/dkum/ec817760-9646-4eab-8181-91f8e3f268e1
 
URL http://doi.wiley.com/10.1111/j.1751-7915.2010.00171.x
 
Language:English
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:In the recent years, the number of drug- and multi-drug-resistant microbial strains has increased rapidly. Therefore, the need to identify innovative approaches for development of novel anti-infectives and new therapeutic targets is of high priority in global health care. The detection of small RNAs (sRNAs) in bacteria has attracted considerable attention as an emerging class of new gene expression regulators. Several experimental technologies to predict sRNA have been established for the Gram-negative model organism Escherichia coli. In many respects, sRNA screens in this model system have set a blueprint for the global and functional identification of sRNAs for Gram-positive microbes, but the functional role of sRNAs in colonization and pathogenicity for Listeria monocytogenes, Staphylococcus aureus, Streptococcuspyogenes, Enterococcus faecalis and Clostridium difficile is almost completely unknown. Here, we report the current knowledge about the sRNAs of these socioeconomically relevant Gram-positive pathogens, overview the state-of-the-art high-throughput sRNA screening methods and summarize bioinformatics approaches for genome-wide sRNA identification and target prediction. Finally, we discuss the use of modified peptide nucleic acids (PNAs) as a novel tool to inactivate potential sRNA and their applications in rapid and specific detection of pathogenic bacteria.
Keywords:anti-infectiveness, peptide nucleic acids, sRNA
Publication status:Published
Publication version:Version of Record
Year of publishing:2010
Number of pages:str. 658-676
Numbering:Letn. 3, št. 6
PID:20.500.12556/DKUM-67175 New window
ISSN:1751-7915
UDC:579
ISSN on article:1751-7915
COBISS.SI-ID:512101944 New window
DOI:10.1111/j.1751-7915.2010.00171.x New window
NUK URN:URN:SI:UM:DK:ID7ZCTRU
Publication date in DKUM:04.08.2017
Views:1452
Downloads:198
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
MRAHEIL, Mobarak, BILLION, André, KUENNE, Carsten, PISCHIMAROV, Jordan, KREIKEMAYER, Bernd, ENGELMANN, Sussane, HARTKE, Axel, GIARD, Jean-Christophe, RUPNIK, Maja, VORWERK, Sonja, BEIER, Markus, RETEY, Julia, HARTSCH, Thomas, JACOB, Anette, CEMIČ, Franz, HEMBERGER, Jürgen, CHAKRABORTY, Trinad and HAIN, Torsten, 2010, Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens : from identification to application. Microbial Biotechnology [online]. 2010. Vol. 3, no. 6, p. 658–676. [Accessed 25 April 2025]. DOI 10.1111/j.1751-7915.2010.00171.x. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=67175
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Record is a part of a journal

Title:Microbial Biotechnology
Shortened title:Microb. Biotechnol.
Publisher:Wiley-Blackwell
ISSN:1751-7915
COBISS.SI-ID:14597398 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:04.08.2017

Secondary language

Language:Slovenian
Keywords:antiinfektivnost, peptidne nukleinske kisline, sRNA


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