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Naslov:Gut microbiota patterns associated with colonization of different clostridium difficile ribotypes
Avtorji:ID Škraban, Jure (Avtor)
ID Džeroski, Sašo (Avtor)
ID Ženko, Bernard (Avtor)
ID Mongus, Domen (Avtor)
ID Gangl, Simon (Avtor)
ID Rupnik, Maja (Avtor)
Datoteke:.pdf PLoS_ONE_2013_Skraban_et_al._Gut_Microbiota_Patterns_Associated_with_Colonization_of_Different_Clostridium_difficile_Ribotypes.PDF (1,01 MB)
MD5: E0F6F0901926476BC9CE90317790EAE9
 
URL http://dx.plos.org/10.1371/journal.pone.0058005
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:Abstract Introduction Materials and Methods Results Discussion Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Figures Abstract C. difficile infection is associated with disturbed gut microbiota and changes in relative frequencies and abundance of individual bacterial taxons have been described. In this study we have analysed bacterial, fungal and archaeal microbiota by denaturing high pressure liquid chromatography (DHPLC) and with machine learning methods in 208 faecal samplesfrom healthy volunteers and in routine samples with requested C. difficile testing. The latter were further divided according to stool consistency, C. difficile presence or absence and C. difficile ribotype (027 or non-027). Lower microbiota diversity was a common trait of all routine samples and not necessarily connected only to C. difficile colonisation. Differences between the healthy donors and C. difficile positive routine samples were detected in bacterial, fungal and archaeal components. Bifidobacterium longum was the single most important species associated with C. difficile negative samples. However, by machine learning approaches we haveidentified patterns of microbiota composition predictive for C. difficile colonization. Those patterns also differed between samples with C. difficile ribotype 027 and other C. difficile ribotypes. The results indicate that not only the presence of a single species/group is important but that certain combinations of gut microbes are associated with C. difficile carriage and that some ribotypes (027) might be associated with more disturbed microbiota than the others.
Ključne besede:microbiota, clostridium difficile, chromatography
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Leto izida:2013
Št. strani:str. 1-13
Številčenje:Letn. 8, št. 2
PID:20.500.12556/DKUM-66277 Novo okno
ISSN:1932-6203
UDK:579
COBISS.SI-ID:16731158 Novo okno
DOI:10.1371/journal.pone.0058005 Novo okno
ISSN pri članku:1932-6203
NUK URN:URN:SI:UM:DK:QW2J3VME
Datum objave v DKUM:19.06.2017
Število ogledov:1486
Število prenosov:403
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
ŠKRABAN, Jure, DŽEROSKI, Sašo, ŽENKO, Bernard, MONGUS, Domen, GANGL, Simon in RUPNIK, Maja, 2013, Gut microbiota patterns associated with colonization of different clostridium difficile ribotypes. PloS one [na spletu]. 2013. Vol. 8, no. 2, p. 1–13. [Dostopano 29 april 2025]. DOI 10.1371/journal.pone.0058005. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=66277
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Gradivo je del revije

Naslov:PloS one
Založnik:Public Library of Science
ISSN:1932-6203
COBISS.SI-ID:2005896 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-4298
Naslov:Vloga okolja in gostitelja pri pojavu in razvoju okužbe s Clostridium difficile

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:19.06.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mikrobiot, clostridium difficile, kromatografija


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