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Title:Gut microbiota patterns associated with colonization of different clostridium difficile ribotypes
Authors:ID Škraban, Jure (Author)
ID Džeroski, Sašo (Author)
ID Ženko, Bernard (Author)
ID Mongus, Domen (Author)
ID Gangl, Simon (Author)
ID Rupnik, Maja (Author)
Files:.pdf PLoS_ONE_2013_Skraban_et_al._Gut_Microbiota_Patterns_Associated_with_Colonization_of_Different_Clostridium_difficile_Ribotypes.PDF (1,01 MB)
MD5: E0F6F0901926476BC9CE90317790EAE9
 
URL http://dx.plos.org/10.1371/journal.pone.0058005
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Abstract Introduction Materials and Methods Results Discussion Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Figures Abstract C. difficile infection is associated with disturbed gut microbiota and changes in relative frequencies and abundance of individual bacterial taxons have been described. In this study we have analysed bacterial, fungal and archaeal microbiota by denaturing high pressure liquid chromatography (DHPLC) and with machine learning methods in 208 faecal samplesfrom healthy volunteers and in routine samples with requested C. difficile testing. The latter were further divided according to stool consistency, C. difficile presence or absence and C. difficile ribotype (027 or non-027). Lower microbiota diversity was a common trait of all routine samples and not necessarily connected only to C. difficile colonisation. Differences between the healthy donors and C. difficile positive routine samples were detected in bacterial, fungal and archaeal components. Bifidobacterium longum was the single most important species associated with C. difficile negative samples. However, by machine learning approaches we haveidentified patterns of microbiota composition predictive for C. difficile colonization. Those patterns also differed between samples with C. difficile ribotype 027 and other C. difficile ribotypes. The results indicate that not only the presence of a single species/group is important but that certain combinations of gut microbes are associated with C. difficile carriage and that some ribotypes (027) might be associated with more disturbed microbiota than the others.
Keywords:microbiota, clostridium difficile, chromatography
Publication status:Published
Publication version:Version of Record
Year of publishing:2013
Number of pages:str. 1-13
Numbering:Letn. 8, št. 2
PID:20.500.12556/DKUM-66277 New window
ISSN:1932-6203
UDC:579
ISSN on article:1932-6203
COBISS.SI-ID:16731158 New window
DOI:10.1371/journal.pone.0058005 New window
NUK URN:URN:SI:UM:DK:QW2J3VME
Publication date in DKUM:19.06.2017
Views:1486
Downloads:402
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
ŠKRABAN, Jure, DŽEROSKI, Sašo, ŽENKO, Bernard, MONGUS, Domen, GANGL, Simon and RUPNIK, Maja, 2013, Gut microbiota patterns associated with colonization of different clostridium difficile ribotypes. PloS one [online]. 2013. Vol. 8, no. 2, p. 1–13. [Accessed 24 April 2025]. DOI 10.1371/journal.pone.0058005. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=66277
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Record is a part of a journal

Title:PloS one
Publisher:Public Library of Science
ISSN:1932-6203
COBISS.SI-ID:2005896 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:J3-4298
Name:Vloga okolja in gostitelja pri pojavu in razvoju okužbe s Clostridium difficile

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:19.06.2017

Secondary language

Language:Slovenian
Keywords:mikrobiot, clostridium difficile, kromatografija


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