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Title:Kronične vnetne črevesne bolezni in rak debelega črevesa in danke
Authors:ID Ocepek, Andreja (Author)
ID Skok, Pavel (Author)
Files:URL http://www.dlib.si/details/URN:NBN:SI:doc-UM0QKCRU
 
Language:Slovenian
Work type:Not categorized
Typology:1.02 - Review Article
Organization:UM - University of Maribor
Abstract:Izhodišča. Rak debelega črevesa in danke je ena najpogostejših rakavih bolezni. Incidenca te vrste raka v razvitih deželah pa tudi v Sloveniji še vedno narašča. Znane so ogrožene skupine ljudi, ki pogosteje ali vedno zbolijo za to boleznijo. Mednje sodijo tudi bolniki s kronično vnetno črevesno boleznijo, ulceroznim kolitisom in Crohnovo boleznijo. Tveganje za raka je največje v skupini bolnikov z razširjenimi vnetnimi spremembami po sluznici debelega črevesa, poveča se po 8 do 10 letih bolezni ter s trajanjem bolezni narašča. Prekancerozna sprememba ni adenom kot pri drugih oblikah raka debelega črevesa in danke, temveč displastična, kronično vnetno spremenjena sluznica. Zaključki. Zelo verjetno je vloga genetskih dejavnikov pri razvoju raka v poteku kroničnih vnetnih črevesnih bolezni drugačna in spremenjena. Bolniki, ki imajo ob ugotovitvi raka že simptome bolezni, imajo slabšo napoved izida, zato je cilj preventivnih programov odkrivanje zgodnjih prekanceroznih sprememb. Uveljavljene presejalne metode temeljijo na sorazmerno pogostih in tako za bolnika kot preiskovalca obremenjujočih endoskopskih preiskavah, tudi koloskopijah. Določanje specifičnih označevalcev ali mutacij kandidatnih genov ter na podlagi genotipizacije oblikovana ocena tveganja za raka debelega črevesa in danke bi omogočile načrtovanje diagnostičnih postopkov pri najbolj ogroženih, olajšala napoved poteka in sledenje bolezni ter odločanje o najprimernejšem zdravljenju.
Year of publishing:2006
Number of pages:str. II-99 - II-103
Numbering:Letn. 75, supl. II
PID:20.500.12556/DKUM-56224 New window
UDC:616.34-006
ISSN on article:1318-0347
COBISS.SI-ID:2491455 New window
NUK URN:URN:SI:UM:DK:M36UJCYL
Publication date in DKUM:21.12.2015
Views:1941
Downloads:54
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
OCEPEK, Andreja and SKOK, Pavel, 2006, Kronične vnetne črevesne bolezni in rak debelega črevesa in danke. Zdravniški vestnik. glasilo Slovenskega zdravniškega društva [online]. 2006. Vol. 75, no. supl. II, p. ii-99- ii–103. [Accessed 14 March 2025]. Retrieved from: http://www.dlib.si/details/URN:NBN:SI:doc-UM0QKCRU
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Record is a part of a journal

Title:Zdravniški vestnik. glasilo Slovenskega zdravniškega društva
Publisher:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 New window

Secondary language

Language:English
Title:Inflammatory bowel disease and colorectal cancer
Abstract:Background. Colorectal cancer is one of the most frequent cancers in developed countries and Slovenia, and the incidence is still rising. Groups of people with higher risk for colorectal cancer are well defined. Among them are patients with inflammatory bowel disease. The risk is highest in patients in whom whole large bowel is affected by inflammation, it rises after 8 to 10 years and increases with the duration of the disease. Precancerous lesion is a displastic, chronically inflammed mucosa and not an adenoma as in cases of sporadic colorectal carcinoma. Conclusions. Many studies suggest that the influence of genetic factors differs between sporadic and inflammatory bowel disease related colorectal cancer. Symptomatic patients at the time of diagnosis have a much worse prognosis. The goal of prevention programes is therefore discovering early precancerous lesions. Established screening protocols are based on relatively frequent colonoscopies which are inconvinient for the patient as well as the endoscopist. Use of specific genetic markers, mutations of candidate genes, as a screening method and a prognostic predictor could greatly lighten therapeutic decisions.


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