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Title:
KARAKTERIZACIJA BIORAZGRADLJIVIH ALGINATNIH AEROGELOV KOT NOSILCEV AKTIVNIH SUBSTANC
Authors:
ID
Koroša, Monika
(Author)
ID
Novak, Zoran
(Mentor)
More about this mentor...
ID
Knez, Željko
(Comentor)
Files:
UNI_Korosa_Monika_2013.pdf
(2,64 MB)
MD5: 881307858E20C9005C0CFCD995908C7F
Language:
Slovenian
Work type:
Bachelor thesis/paper
Typology:
2.11 - Undergraduate Thesis
Organization:
FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:
Naravni polimeri, kot so polisaharidi, se vse bolj uveljavljajo v medicini ter prehrambni industriji. So namreč biokompatibilni, biorazgradljivi, netoksični, stabilni, cenovno dostopni zaradi velikih količin nahajališč v naravi ter spadajo med obnovljive vire. Med take polisaharide spada tudi alginat, katerega vse bolj izkoriščajo zaradi njegovih izjemnih lastnosti. V diplomskem delu smo s sol-gel procesom sintetizirali alginatne gele, kot nosilce aktivne substance, v našem primeru nikotinske kisline, jih nato superkritično posušili s CO2. Dobljene aerogele smo na koncu še analizirali. Nastali aerogeli so izjemno porozni, zaradi česar lahko sproščanje aktivne substance nadzorujemo ter z ustrezno sintezo gela tudi kontroliramo. Za nastanek gela smo uporabili dve različni sredstvi za zamreženje, CaCl2 in BaCl2, ter različne koncentracije alginata. Rezultate analiz smo primerjali med sabo glede na sredstvo zamreženja ter glede na koncentracijo alginata. Opravili smo termoanalitsko DSC analizo, sproščanje aktivne substance, s SEM mikroskopom smo analizirali površino in notranjost nastalega aerogela, ter porozimetrijo.
Keywords:
alginat
,
sol-gel proces
,
aerogel
,
superkritično sušenje
,
nikotinska kislina
,
nadzorovano sproščanje
Place of publishing:
Maribor
Publisher:
[M. Koroša]
Year of publishing:
2013
PID:
20.500.12556/DKUM-42339
UDC:
604.2:547.458(043.2)
COBISS.SI-ID:
17497622
NUK URN:
URN:SI:UM:DK:FMV97OBU
Publication date in DKUM:
02.10.2013
Views:
2066
Downloads:
203
Metadata:
Categories:
KTFMB - FKKT
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Vancouver
:
KOROŠA, Monika, 2013,
KARAKTERIZACIJA BIORAZGRADLJIVIH ALGINATNIH AEROGELOV KOT NOSILCEV AKTIVNIH SUBSTANC
[online]. Bachelor’s thesis. Maribor : M. Koroša. [Accessed 1 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=42339
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Secondary language
Language:
English
Title:
CHARACTERIZATION OF BIODEGRADABLE ALGINATE AEROGELS AS ACTIVE INGREDIENTS CARRIERS
Abstract:
Natural polymers, such as polysaccharides, are gaining in medicine and food industries, because of ther features. Polysaccharides are biocompatible, biodegradable, renewable, non toxic, stable, they have low costs because of their abundance in nature. One of them is alginate, which is increasingly taking advantage of its oustanding characteristics. In the present study we used sol-gel process to synthesized alginate gels as drug carriers in drug delivery systems. As drug we used nicotinic acid. Resulting alginate hydrogels were dried with supercritical CO2 and analyzed afterwards. Aerogels prepared with supercritical drying of hydrogel are extremly porous, resulting controlled drug-loading which can be improved with synthesis and cross-linking agents. To form a gel two different cross-linking agents were used, CaCl2 and BaCl2, and different concentration of alginate. The results of analys were compared according to the agents of cross-linking and by concentration of alginate. We performed DSC,porosimetry, drug-loading of nicotinic acid, with SEM microscope we analyzed surface and inside of the resulting aerogel.
Keywords:
alginate
,
sol-gel process
,
aerogel
,
supercritical drying
,
nicotinic acid
,
controled drug-loading
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