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Title:Heparin adsorption onto model poly(ethylene terephtalate) (PET) surfaces monitored by QCM-D
Authors:ID Doliška, Aleš (Author)
ID Strnad, Simona (Author)
ID Stana-Kleinschek, Karin (Author)
ID Inštitut za kovinske materiale in tehnologije (Copyright holder)
Files:.pdf Materiali_in_Tehnologije_2012_Doliska,_Strnad,_Stana-Kleinschek_Heparin_Adsorption_Onto_Model_Poly(Ethylene_Terephtalate)_(Pet)_Surfaces.pdf (416,79 KB)
MD5: 90C75B6670ABF949C3013197613D9953
PID: 20.500.12556/dkum/4ea643c7-62df-4a05-bb22-3447fc36b3f8
 
URL http://mit.imt.si/Revija/izvodi/mit121/doliska.htm
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Abstract:The adsorption of anticoagulant heparin onto model poly(ethylene terephtalate) (PET) film was monitored using a quartz crystal microbalance with a dissipation unit (QCM-D). Synthetic vascular grafts are usually made from PET, a material with appropriate mechanical properties but moderate haemocompatibility. Therefore anticoagulant heparin is usually used to improve haemocompatibility of PET surfaces. Heparin possesses a high negative charge and as such does not adsorb directly onto hydrophobic PET, which is also negatively charged. To increase heparin adsorption different cationic polymers were investigated as spacers and the highest adsorption was achieved using polyethyleneimine (PEI) as an anchoring agent. The heparin was adsorbed from water solution as well as from phosphate buffer saline (PBS). Heparin dissolved in PBS adsorb better onto PET than heparin from water solution. The results were characterized using Sauerbrey equation and Voigt based viscoelastic model. We found out that heparin adsorbed onto PET formed a thin and rigid film and that Sauerbrey equation is appropriate for characterization of heparin adsorption onto PET.
Keywords:poly(ethyleneterephtalate), PET, heparin, QCM-D, haemocompatibility
Publication status:Published
Publication version:Version of Record
Year of publishing:2012
Number of pages:str. 81-85
Numbering:Letn. 46, št. 1
PID:20.500.12556/DKUM-27248 New window
ISSN:1580-2949
UDC:678.7:61
ISSN on article:1580-2949
COBISS.SI-ID:15775766 New window
NUK URN:URN:SI:UM:DK:UQIVMSEK
Publication date in DKUM:01.06.2012
Views:2042
Downloads:81
Metadata:XML DC-XML DC-RDF
Categories:Misc.
:
DOLIŠKA, Aleš, STRNAD, Simona and STANA-KLEINSCHEK, Karin, 2012, Heparin adsorption onto model poly(ethylene terephtalate) (PET) surfaces monitored by QCM-D. Materiali in tehnologije [online]. 2012. Vol. 46, no. 1, p. 81–85. [Accessed 18 April 2025]. Retrieved from: https://dk.um.si/IzpisGradiva.php?lang=eng&id=27248
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Record is a part of a journal

Title:Materiali in tehnologije
Shortened title:Mater. tehnol.
Publisher:Inštitut za kovinske materiale in tehnologije
ISSN:1580-2949
COBISS.SI-ID:106193664 New window

Secondary language

Language:Slovenian
Title:Spremljanje adsorpcije heparina na modelne polietilentereftalatne (PET) površine s pomočjo kremenove mikrotehtnice
Abstract:Adsorpcijo antikoagulanta heparina na modelni film polietilentereftalata (PET) smo merili s pomočjo kremenove mikrotehtnice s spremljanjem dušenja nihanja (QCM-D). PET, ki se uporablja za izdelavo sintetičnih žilnih vsadkov, ima sicer primerne mehanske lastnosti, vendar slabšo hemokompatibilnost. Heparin, ki izboljša hemokompatibilnost površine polimera v stiku s krvjo, ima močno negativen naboj, zato je njegova adsorpcija na hidrofobni in zato prav tako bolj negativen PET, zanemarljiva. Zato je bilo za uspešno adsorpcijo potrebno uporabiti vmesni vezivni sloj kationskega polimera. Preverili smo učinke več različnih kationskih polimerov in ugotovili, da se heparin najbolje adsorbira na sloj polietilenimina (PEI). Heparin smo adsorbirali iz vodne raztopine in iz fiziološke raztopine (PBS). Heparin se je iz raztopine PBS znatno bolje adsorbiral. Meritve smo ovrednotili z uporabo Sauerbreyeve enačbe in Voigtovega viskoelastičnega modela in ugotovili, da heparin na površini PET tvori čvrst film.
Keywords:polietilentereftalat, PET, heparin, QCM-D, hemokompatibilnost


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