| Naslov: | Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C |
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| Avtorji: | ID Lee, Changhan (Avtor)
ID Klockgether, Jens (Avtor)
ID Fischer, Sebastian (Avtor)
ID Trček, Janja (Avtor)
ID Tümmler, Burkhard (Avtor)
ID Römling, Ute (Avtor) |
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| Datoteke: |  Lee-2020-Why__-_Successful__i_Pseudomonas__i_.pdf (5,39 MB)
MD5: C3BAAEFA712CD1DDEA3ABA65A6C3B1E2
 https://doi.org/10.1093/femsre/fuaa029
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: | FNM - Fakulteta za naravoslovje in matematiko
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| Opis: | The environmental species Pseudomonas aeruginosa thrives in a variety of habitats. Within the epidemic population structure of P. aeruginosa, occassionally highly successful clones that are equally capable to succeed in the environment and the human host arise. Framed by a highly conserved core genome, individual members of successful clones are characterized by a high variability in their accessory genome. The abundance of successful clones might be funded in specific features of the core genome or, although not mutually exclusive, in the variability of the accessory genome. In clone C, one of the most predominant clones, the plasmid pKLC102 and the PACGI-1 genomic island are two ubiquitous accessory genetic elements. The conserved transmissible locus of protein quality control (TLPQC) at the border of PACGI-1 is a unique horizontally transferred compository element, which codes predominantly for stress-related cargo gene products such as involved in protein homeostasis. As a hallmark, most TLPQC xenologues possess a core genome equivalent. With elevated temperature tolerance as a characteristic of clone C strains, the unique P. aeruginosa and clone C specific disaggregase ClpG is a major contributor to tolerance. As other successful clones, such as PA14, do not encode the TLPQC locus, ubiquitous denominators of success, if existing, need to be identified. |
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| Ključne besede: | disaggregase, FtsH, genomic island, protein homeostasis, pulsed field gel electrophoresis, whole genome sequencing |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 17.02.2020 |
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| Datum sprejetja članka: | 12.07.2020 |
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| Datum objave: | 29.09.2020 |
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| Založnik: | Blackwell Publishing |
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| Leto izida: | 2020 |
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| Št. strani: | Str. 740-762 |
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| Številčenje: | Letn. 44, št. 6 |
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| PID: | 20.500.12556/DKUM-91683  |
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| UDK: | 579 |
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| COBISS.SI-ID: | 31111427 |
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| DOI: | 10.1093/femsre/fuaa029 |
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| ISSN pri članku: | 0168-6445 |
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| Datum objave v DKUM: | 28.01.2025 |
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| Število ogledov: | 0 |
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| Število prenosov: | 5 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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