| Naslov: | The role of cAMP in beta cell stimulus-secretion and intercellular coupling |
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| Avtorji: | ID Stožer, Andraž (Avtor)
ID Paradiž, Eva (Avtor)
ID Pohorec, Viljem (Avtor)
ID Dolenšek, Jurij (Avtor)
ID Križančić Bombek, Lidija (Avtor)
ID Gosak, Marko (Avtor)
ID Skelin, Maša (Avtor) |
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| Datoteke: |  Stozer-2021-The_Role_of_cAMP_in_Beta_Cell_Stim.pdf (19,95 MB)
MD5: 5F48968EF753EFF848CD5ABB13AC3B49
 https://doi.org/10.3390/cells10071658
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
FNM - Fakulteta za naravoslovje in matematiko
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| Opis: | Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin hormones, glucagon-like peptide-1 and gastric inhibitory polypeptide, potentiate glucose-stimulated insulin secretion by binding to G protein-coupled receptors, resulting in stimulation of adenylate cyclase and production of the secondary messenger cAMP, which exerts its intracellular effects through activation of protein kinase A or the guanine nucleotide exchange protein 2A. The molecular mechanisms behind these two downstream signaling arms are still not fully elucidated and involve many steps in the stimulus-secretion coupling cascade, ranging from the proximal regulation of ion channel activity to the central Ca2+ signal and the most distal exocytosis. In addition to modifying intracellular coupling, the effect of cAMP on insulin secretion could also be at least partly explained by the impact on intercellular coupling. In this review, we systematically describe the possible roles of cAMP at these intra- and inter-cellular signaling nodes, keeping in mind the relevance for the whole organism and translation to humans. |
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| Ključne besede: | cAMP, beta cells, stimulus-secretion coupling, intercellular coupling, PKA, Epac2A |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 05.05.2021 |
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| Datum sprejetja članka: | 28.06.2021 |
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| Datum objave: | 01.07.2021 |
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| Založnik: | MDPI |
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| Leto izida: | 2021 |
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| Št. strani: | Str. 1-26 |
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| Številčenje: | Letn. 10, št. 7, št. članka 1658 |
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| PID: | 20.500.12556/DKUM-90998  |
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| UDK: | 612.349.7 |
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| COBISS.SI-ID: | 70397955 |
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| DOI: | 10.3390/cells10071658 |
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| ISSN pri članku: | 2073-4409 |
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| Datum objave v DKUM: | 16.10.2024 |
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| Število ogledov: | 0 |
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| Število prenosov: | 4 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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