| Title: | The role of cAMP in beta cell stimulus-secretion and intercellular coupling |
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| Authors: | ID Stožer, Andraž (Author)
ID Paradiž, Eva (Author)
ID Pohorec, Viljem (Author)
ID Dolenšek, Jurij (Author)
ID Križančić Bombek, Lidija (Author)
ID Gosak, Marko (Author)
ID Skelin, Maša (Author) |
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| Files: |  Stozer-2021-The_Role_of_cAMP_in_Beta_Cell_Stim.pdf (19,95 MB)
MD5: 5F48968EF753EFF848CD5ABB13AC3B49
 https://doi.org/10.3390/cells10071658
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.02 - Review Article |
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| Organization: | MF - Faculty of Medicine
FNM - Faculty of Natural Sciences and Mathematics
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| Abstract: | Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin hormones, glucagon-like peptide-1 and gastric inhibitory polypeptide, potentiate glucose-stimulated insulin secretion by binding to G protein-coupled receptors, resulting in stimulation of adenylate cyclase and production of the secondary messenger cAMP, which exerts its intracellular effects through activation of protein kinase A or the guanine nucleotide exchange protein 2A. The molecular mechanisms behind these two downstream signaling arms are still not fully elucidated and involve many steps in the stimulus-secretion coupling cascade, ranging from the proximal regulation of ion channel activity to the central Ca2+ signal and the most distal exocytosis. In addition to modifying intracellular coupling, the effect of cAMP on insulin secretion could also be at least partly explained by the impact on intercellular coupling. In this review, we systematically describe the possible roles of cAMP at these intra- and inter-cellular signaling nodes, keeping in mind the relevance for the whole organism and translation to humans. |
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| Keywords: | cAMP, beta cells, stimulus-secretion coupling, intercellular coupling, PKA, Epac2A |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 05.05.2021 |
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| Article acceptance date: | 28.06.2021 |
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| Publication date: | 01.07.2021 |
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| Publisher: | MDPI |
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| Year of publishing: | 2021 |
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| Number of pages: | Str. 1-26 |
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| Numbering: | Letn. 10, št. 7, št. članka 1658 |
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| PID: | 20.500.12556/DKUM-90998  |
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| UDC: | 612.349.7 |
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| ISSN on article: | 2073-4409 |
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| COBISS.SI-ID: | 70397955 |
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| DOI: | 10.3390/cells10071658 |
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| Publication date in DKUM: | 16.10.2024 |
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| Views: | 0 |
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| Downloads: | 4 |
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| Metadata: |    |
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| Categories: | Misc.
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