| Title: | Lipoprotein(a) as a risk factor in a cohort of hospitalised cardiovascular patients : A retrospective clinical routine data analysis |
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| Authors: | ID Šuran, David (Author)
ID Završnik, Tadej (Author)
ID Kokol, Peter (Author)
ID Kokol, Marko (Author)
ID Sinkovič, Andreja (Author)
ID Naji, Franjo (Author)
ID Završnik, Jernej (Author)
ID Blažun Vošner, Helena (Author)
ID Kanič, Vojko (Author) |
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| Files: |  jcm-12-03220-v2.pdf (285,58 KB)
MD5: 9F6C7E699DCEEE836FCAAA0546EC8D1B
 https://www.mdpi.com/2077-0383/12/9/3220
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FERI - Faculty of Electrical Engineering and Computer Science
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| Abstract: | Lipoprotein(a) (Lp(a)) is a well-recognised risk factor for ischemic heart disease (IHD) and calcific aortic valve stenosis (AVS). Methods: A retrospective observational study of Lp(a) levels (mg/dL) in patients hospitalised for cardiovascular diseases (CVD) in our clinical routine was performed. The Lp(a)-associated risk of hospitalisation for IHD, AVS, and concomitant IHD/AVS versus other non-ischemic CVDs (oCVD group) was assessed by means of logistic regression. Results: In total of 11,767 adult patients, the association with Lp(a) was strongest in the IHD/AVS group (eβ = 1.010, p < 0.001), followed by the IHD (eβ = 1.008, p < 0.001) and AVS group (eβ = 1.004, p < 0.001). With increasing Lp(a) levels, the risk of IHD hospitalisation was higher compared with oCVD in women across all ages and in men aged ≤75 years. The risk of AVS hospitalisation was higher only in women aged ≤75 years (eβ = 1.010 in age < 60 years, eβ = 1.005 in age 60–75 years, p < 0.05). Conclusions: The Lp(a)-associated risk was highest for concomitant IHD/AVS hospitalisations. The differential impact of sex and age was most pronounced in the AVS group with an increased risk only in women aged ≤75 years. |
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| Keywords: | acute myocardial infarction, aortic valve stenosis, atherosclerosis, cardiovascular diseases, cardiovascular risk, ischemic heart disease, lipoprotein(a), postmenopausal women |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 02.03.2023 |
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| Article acceptance date: | 27.04.2023 |
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| Publication date: | 29.04.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | [1]-10 str. |
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| Numbering: | Vol. 12, issue 9, [article no.] 3220 |
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| PID: | 20.500.12556/DKUM-89079  |
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| UDC: | 616.1 |
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| ISSN on article: | 2077-0383 |
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| COBISS.SI-ID: | 151715843 |
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| DOI: | 10.3390/jcm12093220 |
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| Copyright: | © 2023 by the authors |
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| Publication date in DKUM: | 12.06.2024 |
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| Views: | 137 |
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| Downloads: | 11 |
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| Metadata: |    |
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| Categories: | Misc.
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