| Title: | The role of oxidative stress in kidney injury |
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| Authors: | ID Piko, Nejc (Author)
ID Bevc, Sebastjan (Author)
ID Hojs, Radovan (Author)
ID Ekart, Robert (Author) |
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| Files: |  Piko-2023-The_Role_of_Oxidative_Stress_in_Kidn.pdf (1007,69 KB)
MD5: 50D8241F1A8B8162B070625B0B0EFA19
 https://doi.org/10.3390/antiox12091772
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.02 - Review Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Acute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury’s most common clinical sequelae is increased cardiovascular morbidity and mortality. In recent years, new insights into the pathophysiology of renal damage have been made. Oxidative stress is the imbalance favoring the increased generation of ROS and/or reduced body’s innate antioxidant defense mechanisms and is of pivotal importance, not only in the development and progression of kidney disease but also in understanding the enhanced cardiovascular risk in these patients. This article summarizes and emphasizes the role of oxidative stress in acute kidney injury, various forms of chronic kidney disease, and also in patients on renal replacement therapy (hemodialysis, peritoneal dialysis, and after kidney transplant). Additionally, the role of oxidative stress in the development of drug-related nephrotoxicity and also in the development after exposure to various environmental and occupational pollutants is presented. |
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| Keywords: | acute kidney injury, acute tubular necrosis, chronic kidney disease, oxidative stress, reactive oxygen species |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 26.07.2023 |
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| Article acceptance date: | 15.09.2023 |
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| Publication date: | 16.09.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | Str. 1-13 |
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| Numbering: | Vol. 12, Št. 9, št. članka 1772 |
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| PID: | 20.500.12556/DKUM-87506  |
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| UDC: | 616.6 |
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| ISSN on article: | 2076-3921 |
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| COBISS.SI-ID: | 164888579 |
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| DOI: | 10.3390/antiox12091772 |
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| Publication date in DKUM: | 19.03.2024 |
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| Views: | 210 |
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| Downloads: | 32 |
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| Metadata: |    |
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| Categories: | Misc.
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