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Title:Motnje socialne kognicije pri amiotrofični lateralni sklerozi : magistrsko delo
Authors:ID Kadenšek, Sara (Author)
ID Štukovnik, Vita (Mentor) More about this mentor... New window
ID Koritnik, Blaž (Comentor)
Files:.pdf MAG_Kadensek_Sara_2024.pdf (973,11 KB)
MD5: ACAC97CB0071E1F89BFA65908583D0B7
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FF - Faculty of Arts
Abstract:Amiotrofična lateralna skleroza (ALS) je napredujoča nevrodegenerativna bolezen, ki prizadene motorične nevrone v možganih in hrbtenjači. To vodi v mišično atrofijo, šibkost, lahko pa vpliva tudi na kognitivne funkcije. Oškodovana socialna kognicija je ena od kognitivnih sprememb, ki se lahko pojavijo pri bolezni ALS. Glavni cilj te raziskave je bil oceniti sposobnosti na področju socialne kognicije pri bolnikih z ALS v primerjavi s kontrolno skupino. Želeli smo preučiti, kako se stopnja motorične okvare in trajanje bolezni povezujeta z oškodovano socialno kognicijo, ali obstajajo razlike v socialni kogniciji med bolniki z ALS z bulbarnim začetkom in tistimi s spinalnim začetkom, ter ugotoviti, katera izmed domen socialne kognicije je pri bolnikih z ALS najizraziteje oškodovana. Skupno 30 bolnikov z ALS in 29 zdravih kontrol, usklajenih po starosti, spolu in izobrazbi, je rešilo podtest socialne kognicije na Edinburškem kognitivnem in vedenjskem presejalnem preizkusu za ALS (SK ECAS), Test prepoznavanja emocionalnih izrazov iz oči (RMET) in Edinburški test socialne kognicije (ESCoT). Ključna ugotovitev naše raziskave je, da bolniki z ALS dosegajo statistično značilno slabše rezultate na SK ECAS in ESCoT v primerjavi s kontrolno skupino. Obenem ugotavljamo, da ni povezave med stopnjo motorične okvare, opredeljeno z Dopolnjeno funkcijsko ocenjevalno lestvico za ALS (ALSFRS-R), in oškodovano socialno kognicijo. Prav tako nismo dokazali povezave med trajanjem bolezni in oškodovanostjo socialne kognicije. Potrdili pa smo, da bolniki z bulbarnim začetkom bolezni dosegajo statistično značilno slabše rezultate na RMET in ESCoT v primerjavi z bolniki s spinalnim začetkom. Dodatno smo ugotovili, da imajo bolniki z ALS največ težav na področju kognitivne teorije uma. Izsledki raziskave potrjujejo, da imajo lahko bolniki z ALS oškodovano socialno kognicijo. Ugotovitve predstavljajo izhodišče za prihodnje raziskave socialne kognicije, kar bi pripomoglo k boljšemu razumevanju kognitivnih značilnosti bolezni ALS, z namenom izboljšanja splošne kakovosti življenja bolnikov z ALS in tudi njihovih skrbnikov.
Keywords:amiotrofična lateralna skleroza, kognitivne motnje in frontotemporalna demenca, socialna kognicija, teorija uma
Place of publishing:Maribor
Place of performance:Maribor
Publisher:S. Kadenšek
Year of publishing:2024
Number of pages:1 spletni vir (1 datoteka PDF (XII, 123 str.))
PID:20.500.12556/DKUM-87162 New window
UDC:616.8:159.9(043.2)
COBISS.SI-ID:191350787 New window
Publication date in DKUM:04.04.2024
Views:220
Downloads:39
Metadata:XML DC-XML DC-RDF
Categories:FF
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:27.02.2024

Secondary language

Language:English
Title:Social cognition impairment in amyotrophic lateral sclerosis
Abstract:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that affects the motor neurons in the brain and spinal cord. This results in muscle atrophy, weakness, and potentially affects cognitive functions. Cognitive changes in individuals with ALS may manifest as deficiencies in social cognition. The primary objective of this research was to evaluate social cognitive abilities in patients diagnosed with ALS in comparison to a control group. Moreover, the study aimed to examine how the severity of motor impairment and the duration of the disease correlate to deficits in social cognition. The investigation sought to uncover variations in social cognition between ALS patients with onset in the bulbar region and those with spinal onset. We also wanted to explore the specific domains of social cognition that exhibit the most pronounced impairments in ALS patients. A total of 30 ALS patients and 29 controls, matched by age, gender, and education, underwent a social cognition evaluation using the Social Cognition subtest on the Edinburgh Cognitive and Behavioral ALS Screen (SC ECAS), the Reading the Mind in the Eyes Test (RMET), and the Edinburgh Social Cognition Test (ESCoT). Key findings of our research is that ALS patients demonstrated significantly poorer performance in SC ECAS and ESCoT in comparison to controls. We detected no correlation between motor impairment as assessed by the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) and impairment in social cognition. There was no correlation between disease duration and social cognition impairment. Patients with bulbar onset showed significantly poorer performance compared to patients with spinal onset on RMET and on ESCoT. Our findings indicate that individuals with ALS exhibited the lowest performance specifically in the domain of cognitive theory of mind. The research findings confirm impairments of social cognition in ALS patients. These findings can serve as a basis for further research of social cognition, contributing to a better understanding of cognitive aspect in ALS, with the aim of improving the overall quality of life of ALS patients and their caregivers.
Keywords:amyotrophic lateral sclerosis, cognitive impairment and frontotemporal dementia, social cognition, theory of mind


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