| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font

Show document Help

Title:UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing–remitting type of multiple sclerosis
Authors:ID Görska, Ewelina (Author)
ID Tylicka, Marzena (Author)
ID Hermanowicz, Adam (Author)
ID Matuszczak, Ewa (Author)
ID Sankiewicz, Anna (Author)
ID Gorodkiewicz, Ewa (Author)
ID Hermanowicz, Justyna (Author)
ID Karpińska, Elźbieta (Author)
ID Socha, Katarzyna (Author)
ID Kochanowicz, Jan (Author)
ID Homšak, Evgenija (Author)
Files:.pdf Górska-2023-UCHL1,_besides_leptin_and_fibronec.pdf (1,24 MB)
MD5: 64688FD3399558A6896539A5DEB73039
URL https://doi.org/10.1038/s41598-023-30237-3
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Research on the markers of immunoregulatory response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of leptin, fibronectin, and UCHL1 concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface Plasmon Resonance Imaging (SPRI) biosensors were used for the evaluation of proteins concentrations in 100 RRMS patients and 46 healthy volunteers. Plasma leptin, fibronectin, and UCHL1 concentrations were significantly higher in RRMS patients compared to the control group (p < 0.001, respectively). UCHL1 concentration evaluation revealed the highest diagnostic sensitivity (100%) and negative predictive value (100%) in differentiating MS patients from healthy individuals. There was no significant difference in the UCHL1 concentrations depending on the patient's sex, the presence of relapse within the last 24 months, and the EDSS value (p > 0.05, respectively). In RRMS patients UCHL1 concentration positively correlated with fibronectin levels (r = 0.3928; p < 0.001). In the current cohort of patients plasma UCHL1 concentration was independent of the time of MS relapse and the severity of neurological symptoms. Thus current study may indicate that plasma UCHL1, besides leptin and fibronectin, also could be a promising high-sensitive potential biomarker of relapsing-remitting type of MS. However, these results should be validated with a larger group of patients, taking into account neuroimaging and cerebrospinal fluid analysis data, and by comparing them to patients with other neurological diseases as a control group.
Keywords:immunoregulatory response, multiple sclerosis, biomarkers, leptin, fibronectins, ubiquitin thiolesterase
Publication status:Published
Publication version:Version of Record
Submitted for review:08.11.2022
Article acceptance date:20.02.2023
Publication date:28.02.2023
Publisher:Nature Publishing Group
Year of publishing:2023
Number of pages:Str. 1-10
Numbering:Letn. 13, Št. članka 3423
PID:20.500.12556/DKUM-87128 New window
ISSN on article:2045-2322
COBISS.SI-ID:143814659 New window
DOI:10.1038/s41598-023-30237-3 New window
Publication date in DKUM:21.02.2024
Copy citation
Average score:(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share

Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Scientific reports
Shortened title:Sci. rep.
Publisher:Nature Publishing Group
COBISS.SI-ID:18727432 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:28.02.2023

Secondary language

Keywords:imunoregulacijski odziv, multipla skleroza, biomarkerji, leptin, fibronektini, ubikvitin tioesteraza


Leave comment

You must log in to leave a comment.

Comments (0)
0 - 0 / 0
There are no comments!

Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica