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Title:Peripheral blood transcriptome in breast cancer patients as a source of less invasive immune biomarkers for personalized medicine, and implications for triple negative breast cancer
Authors:ID Čelešnik, Helena Sabina (Author)
ID Potočnik, Uroš (Author)
Files:.pdf Peripheral_Blood_Transcriptome_i-Celesnik-2022.pdf (1,74 MB)
MD5: 616993E41B421AF14BADEB86410B6F00
URL https://www.mdpi.com/2072-6694/14/3/591
URL https://doi.org/10.3390/cancers14030591
Work type:Scientific work
Typology:1.02 - Review Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
MF - Faculty of Medicine
Abstract:Transcriptome studies of peripheral blood cells can advance our understanding of the systemic immune response to the presence of cancer and the mechanisms underlying cancer onset and progression. This enables the identification of novel minimally invasive immune biomarkers for early cancer detection and personalized cancer management and may bring forward new immunotherapy options. Recent blood gene expression analyses in breast cancer (BC) identified distinct patient subtypes that differed in the immune reaction to cancer and were distinct from the clinical BC subtypes, which are categorized based on expression of specific receptors on tumor cells. Introducing new BC subtypes based on peripheral blood gene expression profiles may be appropriate, since it may assist in BC prognosis, the identification of patients likely to benefit from immunotherapy, and treatment efficacy monitoring. Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous, and difficult-to-treat disease, and identification of novel biomarkers for this BC is crucial for clinical decision-making. A few studies have reported TNBC-enriched blood transcriptional signatures, mostly related to strong inflammation and augmentation of altered immune signaling, that can differentiate TNBC from other classical BC subtypes and facilitate diagnosis. Future research is geared toward transitioning from expression signatures in unfractionated blood cells to those in immune cell subpopulations.
Keywords:triple negative breast cancer, transcriptome, peripheral blood, PBMC, gene expression, immune biomarker
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2022
Year of publishing:2022
Number of pages:str. 1-21
Numbering:Letn. 14, Št. 3
PID:20.500.12556/DKUM-85256 New window
ISSN on article:2072-6694
COBISS.SI-ID:94899715 New window
DOI:10.3390/cancers14030591 New window
Publication date in DKUM:23.08.2023
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Record is a part of a journal

Shortened title:Cancers
COBISS.SI-ID:517914137 New window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0067
Name:Farmakologija in farmakogenomika

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0427
Name:Sistemski pristopi k raziskavam človeškega genoma za personalizirano medicino kroničnih imunskih bolezni

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J3-9272
Name:Identifikacija molekularnih biooznačevalcev za napoved kliničnega poteka in zasevanja pri pacientkah s trojno negativnim rakom dojke.


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Keywords:trojni negativni rak dojke, transkriptom, periferna kri, PBMC, izražanje genov, biomarkerji


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