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Title:Bioactive coatings with anti-osteoclast therapeutic agents for bone implant : enhanced compliance and prolonged implant life
Authors:ID Bjelić, Dragana (Author)
ID Finšgar, Matjaž (Author)
Files:.pdf Bioactive_coatings_with_anti-osteo-Bjelic-2022.pdf (1,89 MB)
MD5: 2AD98120AD450261C5517961B13C830F
URL https://www.sciencedirect.com/science/article/pii/S1043661822000056?via%3Dihub
Work type:Scientific work
Typology:1.02 - Review Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:The use of therapeutic agents that inhibit bone resorption is crucial to prolong implant life, delay revision surgery, and reduce the burden on the healthcare system. These therapeutic agents include bisphosphonates, various nucleic acids, statins, proteins, and protein complexes. Their use in systemic treatment has several drawbacks, such as side effects and insufficient efficacy in terms of concentration, which can be eliminated by local treatment. This review focuses on the incorporation of osteoclast inhibitors (antiresorptive agents) into bioactive coatings for bone implants. The ability of bioactive coatings as systems for local delivery of antiresorptive agents to achieve optimal loading of the bioactive coating and its release is described in detail. Various parameters such as the suitable concentrations, release times, and the effects of the antiresorptive agents on nearby cells or bone tissue are discussed. However, further research is needed to support the optimization of the implant, as this will enable subsequent personalized design of the coating in terms of the design and selection of the coating material, the choice of an antiresorptive agent and its amount in the coating. In addition, therapeutic agents that have not yet been incorporated into bioactive coatings but appear promising are also mentioned. From this work, it can be concluded that therapeutic agents contribute to the biocompatibility of the bioactive coating by enhancing its beneficial properties.
Keywords:bioactive coatings, implants, bone resorption, osteolysis, osteoclats inhibitors
Publication status:Published
Publication version:Version of Record
Publication date:01.02.2022
Year of publishing:2022
Number of pages:15 str.
Numbering:Vol. 176
PID:20.500.12556/DKUM-85066 New window
ISSN on article:1043-6618
COBISS.SI-ID:92991491 New window
DOI:10.1016/j.phrs.2022.106060 New window
Publication date in DKUM:17.08.2023
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Record is a part of a journal

Title:Pharmacological research
Shortened title:Pharmacol. res.
Publisher:Academic Press
COBISS.SI-ID:27680256 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P2-0118-2022
Name:Tekstilna kemija in napredni tekstilni materiali

Funder:ARRS - Slovenian Research Agency
Project number:J1-2470
Name:Biofunkcionalizacija 3D-tiskanih kovinskih zlitin kot novo nastajajoča strategija za zmanjšanje neželenih učinkov ortopedskih vsadkov


License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Keywords:bioaktivni premazi, vsadki, resorpcija kosti, osteoliza, zaviralci osteoklastov


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